05623nam 22011893u 450 991013959150332120230725053517.01-283-28323-997866132832381-4443-4634-21-4443-4631-8(CKB)2550000000054394(EBL)819327(OCoLC)758981647(SSID)ssj0000607896(PQKBManifestationID)11407859(PQKBTitleCode)TC0000607896(PQKBWorkID)10591206(PQKB)10532292(MiAaPQ)EBC819327(EXLCZ)99255000000005439420131021d2011|||| u|| |engur|n|---|||||txtccrAdvanced Therapy for Hepatitis C[electronic resource]Hoboken Wiley20111 online resource (233 p.)Description based upon print version of record.1-4051-8745-X Advanced Therapy for Hepatitis C; Contents; Contributors; Preface; Section I Foundations for Understanding Antiviral Therapies in HCV; 1 HCV Replication; 2 Hepatitis C Virus Genotypes; 3 Immune Responses to HCV: Implications for Therapy; 4 Mechanisms of Action of Antiviral Drugs: The Interferons; 5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs; 6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors; 7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors; 8 Measuring Antiviral ResponsesSection II Efficacy and Clinical Use of Antiviral Therapies9 Genotype 1: Standard Treatment; 10 Individually Tailored Treatment Strategies in Treatment-naïve Chronic Hepatitis C Genotype 1 Patients; 11 Genotype 1 Relapsers and Non-responders; 12 Standard Therapy for Genotypes 2/3; 13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3; 14 Genotypes 2 and 3 Relapse and Non-response; 15 Hepatitis C Genotype 4 Therapy: Progress and Challenges; 16 Antivirals in Acute Hepatitis C; 17 Antivirals in Cirrhosis and Portal Hypertension18 Treatment of Recurrent Hepatitis C Following Liver Transplantation19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations; 20 Cytopenias: How they Limit Therapy and Potential Correction; 21 The Problem of Insulin Resistance and its Effect on Therapy; 22 HIV and Hepatitis C Co-infection; 23 HCV and Racial Differences; 24 HCV and the Pediatric Population; 25 New Horizons: IL28, Direct-acting Antiviral Therapy for HCV; IndexHepatologists, both researchers and front-line clinicians, now have a comprehensive guide to the treatment of patients with the HCV virus. This book focuses mainly on the efficacy and clinical use of antiviral therapies, including the use of antivirals post liver transplantation and in the presence of the HIV virus. It also explores the foundations for understanding antiviral therapies in HCV, such as the complex pharmacology and mechanisms of antiviral drugs. A 'late-breaking information' chapter contains the most recent trial results on the latest antiviral drugs.Antiviral agentsAntiviral Agents - therapeutic useAntiviral Agents -- therapeutic useAntiviral agentsHepatitis C - therapyHepatitis C -- therapyHepatitis C - TreatmentHepatitis C -- TreatmentHepatitis CTreatmentAntiviral agentsHepatitis, Viral, HumanFlaviviridae InfectionsAnti-Infective AgentsRNA Virus InfectionsTherapeutic UsesVirus DiseasesHepatitisDiseasesLiver DiseasesPharmacologic ActionsChemical Actions and UsesDigestive System DiseasesAntiviral AgentsHepatitis CMedicineHILCCHealth & Biological SciencesHILCCGastroenterologyHILCCAntiviral agents.Antiviral Agents - therapeutic use.Antiviral Agents -- therapeutic use.Antiviral agents.Hepatitis C - therapy.Hepatitis C -- therapy.Hepatitis C - Treatment.Hepatitis C -- Treatment.Hepatitis CTreatmentAntiviral agentsHepatitis, Viral, HumanFlaviviridae InfectionsAnti-Infective AgentsRNA Virus InfectionsTherapeutic UsesVirus DiseasesHepatitisDiseasesLiver DiseasesPharmacologic ActionsChemical Actions and UsesDigestive System DiseasesAntiviral AgentsHepatitis CMedicineHealth & Biological SciencesGastroenterology616.3/62306616.362306McCaughan Geoffrey W943121McHutchison John943122Pawlotsky Jean-Michel943123AU-PeELAU-PeELAU-PeELBOOK9910139591503321Advanced Therapy for Hepatitis C2128358UNINA