05683nam 2200709Ia 450 991013955890332120230803075350.01-283-33226-497866133322641-118-13538-51-118-13539-31-118-13536-9(CKB)2550000000064527(EBL)818454(OCoLC)768230312(SSID)ssj0000538448(PQKBManifestationID)11331452(PQKBTitleCode)TC0000538448(PQKBWorkID)10559164(PQKB)10142768(MiAaPQ)EBC818454(Au-PeEL)EBL818454(CaPaEBR)ebr10510539(CaONFJC)MIL333226(EXLCZ)99255000000006452720110611d2012 uy 0engur|n|---|||||txtccrLC-NMR and other hyphenated NMR techniques[electronic resource] overview and applications /Maria Victoria Silva ElipeHoboken, NJ :Wiley,c2012.1 online resource (240 p.)THEi Wiley ebooksDescription based upon print version of record.0-470-54834-7 Includes bibliographical references and index.LC-NMR and Other Hyphenated NMR Techniques: Overview and Applications; Contents; Preface; Abbreviations, Symbols, and Units; 1. Basic Concepts of NMR Spectroscopy; 1.1 Introduction; 1.2 Basic Knowledge Regarding the Physics of NMR Spectroscopy; 1.3 Basic Parameters for NMR Interpretation; 1.3.1 Chemical Shift; 1.3.2 Spin-Spin Coupling Constants; 1.3.3 Spin Systems; 1.3.4 Signal Intensities; 1.3.5 Bond Correlations; 1.3.6 Spatial Correlations; 1.3.7 Other Topics; 1.4 Conclusions; References; 2. Historical Development of NMR and LC-NMR; 2.1 Introduction; 2.2 Historical Development of NMR2.3 Historical Development of LC-NMR2.4 Historical Development of Other Analytical Techniques Hyphenated with NMR; 2.5 Current Trends; References; 3. Basic Technical Aspects and Operation of LC-NMR and LC-MS-NMR; 3.1 Introduction; 3.2 Technical Considerations Regarding LC-NMR; 3.2.1 Solvent Compatibility; 3.2.2 Solvent Suppression; 3.2.3 NMR Flow Cell; 3.2.4 LC-NMR Sensitivity; 3.3 Technical Considerations Regarding LC-MS-NMR; 3.3.1 Deuterated Solvents; 3.4 Modes of Operation of LC-NMR; 3.4.1 On-Flow Mode; 3.4.2 Stop-Flow Mode; 3.4.3 Time-Sliced Mode; 3.4.4 Loop Collection Mode3.5 Modes of Operation of LC-MS-NMR3.5.1 On-Flow Mode; 3.5.2 Stop-Flow Mode; 3.6 Other Modes of Operation; 3.7 Challenging Considerations; 3.7.1 Air Bubbles; 3.7.2 Carryover with and Without an Autosampler; 3.7.3 Sample Solubility and Precipitation; 3.7.4 Flow Cell and System Cleaning; 3.7.5 Flow Rate and Magnetic Susceptibility; 3.7.6 Quantitation; 3.8 Conclusions; References; 4. Applications of LC-NMR; 4.1 Introduction; 4.2 Applications of LC-NMR; 4.2.1 Natural Products; 4.2.2 Drug Metabolism; 4.2.3 Drug Discovery; 4.2.4 Impurity Characterization; 4.2.5 Degradation Products4.2.6 Food Analysis4.2.7 Polymers; 4.2.8 Metabolomics and Metabonomics; 4.2.9 Isomers, Tautomers, and Chiral Compounds; 4.2.10 Others Areas; 4.3 Conclusions and Future Trends; References; 5. Applications of LC-MS-NMR; 5.1 Introduction; 5.2 Applications of LC-MS-NMR; 5.2.1 Natural Products; 5.2.2 Drug Metabolism; 5.2.3 Drug Discovery and Development; 5.2.4 Metabolomics and Metabonomics; 5.2.5 Others Areas; 5.3 Conclusions and Future Trends; References; 6. Hyphenation of NMR with Other Analytical Separation Techniques; 6.1 Introduction; 6.2 GC-NMR; 6.3 GPC-NMR; 6.4 SEC-NMR; 6.5 SFC-NMR6.6 SFE-NMR6.7 CE-NMR; 6.8 CEC-NMR; 6.9 CZE-NMR; 6.10 cITP-NMR; 6.11 CapLC-NMR; 6.12 SPE-NMR; 6.13 SPE-MS-NMR; 6.14 Conclusions and Future Trends; References; 7. Special Topics and Applications Related to LC-NMR; 7.1 Introduction; 7.2 Off-Line Versus Online NMR for Structural Elucidation; 7.2.1 Cases Solved Off-Line; 7.2.2 Cases Solved Online; 7.3 Analysis of Chiral Molecules by NMR; 7.3.1 Classical Approach: Off-Line; 7.3.2 Nonclassical Approach: Online; 7.4 Monitoring Chemical Reactions In Situ; 7.4.1 Classical Approach: Off-Line; 7.4.2 Nonclassical Approach: Online7.5 Analysis of Mixtures Off-Line, Online, and by Other NMR MethodologiesThis practical guide provides a basic overview of the pros and cons of NMR spectroscopy as both a hyphenated and non-hyphenated technique. The book begins with a description of basic NMR concepts for the structural elucidation of organic compounds and then details the historical development of NMR and hyphenated NMR in the structural elucidation world, followed by applications of hyphenated NMR as LC-NMR and LC-MS-NMR in industry and academia. It also contains updated information on the latest advancements and applications of LC-NMR in such areas as degradation products, drug metabolism, foodTHEi Wiley ebooks.Nuclear magnetic resonance spectroscopyIndustrial applicationsOrganic compoundsAnalysisDrug developmentNuclear magnetic resonance spectroscopyIndustrial applications.Organic compoundsAnalysis.Drug development.543/.66SCI078000bisacshSilva Elipe Maria V.1963-996116MiAaPQMiAaPQMiAaPQBOOK9910139558903321LC-NMR and other hyphenated NMR techniques2282766UNINA