05474nam 2200685 450 991013939940332120170810173627.00-470-66522-X0-470-66519-X(CKB)2480000000008344(EBL)699355(OCoLC)811498650(SSID)ssj0000506247(PQKBManifestationID)11303556(PQKBTitleCode)TC0000506247(PQKBWorkID)10513821(PQKB)11714162(MiAaPQ)EBC699355(MiAaPQ)EBC7076180(Au-PeEL)EBL7076180(EXLCZ)99248000000000834420160817h20112011 uy 0engur|n|---|||||txtccrDrug disposition and pharmacokinetics from principles to applications /Stephen H. Curry, Robin Whelpton2nd ed.Chichester, West Sussex, England :Wiley-Blackwell,2011.©20111 online resource (840 p.)Description based upon print version of record.0-470-68446-1 Includes bibliographical references at the end of each chapters and index.Cover; Title; Copyright; Preface; About the Authors; 1: Chemical Introduction: Sources, Classification and Chemical Properties of Drugs; 1.1 Introduction; 1.2 Drug nomenclature and classification; 1.3 Properties of molecules; 1.4 Physicochemical interactions between drugs and other chemicals; 1.5 Law of mass action; 1.6 Ionization; 1.7 Partition coefficients; 1.8 Stereochemistry; Further reading and references; 2: Drug Administration and Distribution; 2.1 Introduction; 2.2 Drug transfer across biological membranes; 2.3 Drug administration; 2.4 Drug distribution; 2.5 Plasma protein binding2.6 SummaryReferences and further reading; 3: Drug Elimination; 3.1 Introduction; 3.2 Metabolism; 3.3 Excretion; References and further reading; 4: Elementary Pharmacokinetics; 4.1 Introduction; 4.2 Single-compartment models; 4.3 Non-linear kinetics; 4.4 Relationship between dose, onset and duration of effect; 4.5 Limitations of single-compartment models; 4.6 Summary; References and further reading; 5: More Complex and Model Independent Pharmacokinetic Models; 5.1 Introduction; 5.2 Multiple compartment models; 5.3 Curve fitting and choice of most appropriate model5.4 Model independent approaches5.5 Population pharmacokinetics; 5.6 Summary; References and further reading; 6: Kinetics of Metabolism and Excretion; 6.1 Introduction; 6.2 Metabolite kinetics; 6.3 Renal excretion; 6.4 Excretion in faeces; References and further reading; 7: Further Consideration of Clearance, and Physiological Modelling; 7.1 Introduction; 7.2 Clearance in vitro (metabolic stability); 7.3 Clearance in vivo; 7.4 Hepatic intrinsic clearance; 7.5 In vitro to in vivo extrapolation; 7.6 Limiting values of clearance; 7.7 Safe and effective use of clearance7.8 Physiological modelling7.9 Inhomogeneity of plasma; References and further reading; 8: Drug Formulation: Bioavailability, Bioequivalence and Controlled-Release Preparations; 8.1 Introduction; 8.2 Dissolution; 8.3 Systemic availability; 8.4 Formulation factors affecting bioavailability; 8.5 Bioequivalence; 8.6 Controlled-release preparations; 8.7 Conclusions; References and further reading; 9: Factors Affecting Plasma Concentrations; 9.1 Introduction; 9.2 Time of administration of dose; 9.3 Food, diet and nutrition; 9.4 Smoking; 9.5 Circadian rhythms; 9.6 Weight and obesity; 9.7 Sex9.8 Pregnancy9.9 Ambulation, posture and exercise; References and further reading; 10: Pharmacogenetics and Pharmacogenomics; 10.1 Introduction; 10.2 Methods for the study of pharmacogenetics; 10.3 N-acetyltransferase; 10.4 Plasma cholinesterase; 10.5 Cytochrome P450 polymorphisms; 10.6 Alcohol dehydrogenase and acetaldehyde dehydrogenase; 10.7 Thiopurine methyltransferase; 10.8 Phase 2 enzymes; 10.9 Transporters; 10.10 Pharmacodynamic differences; References and further reading; 11: Developmental Pharmacology and Age-related Phenomena; 11.1 Introduction11.2 Scientific and regulatory environment in regard to younger and older patientsThis is an authoritative, comprehensive book on the fate of drug molecules in the body, including implications for pharmacological and clinical effects. The text provides a unique, balanced approach, examining the specific physical and biological factors affecting the absorption, distribution, metabolism and excretion of drugs, together with mathematical assessment of the concentrations in plasma and body fluids. Understanding the equations requires little more than a basic knowledge of algebra, laws of indices and logarithms, and very simple calculus. A companion web site contains additional PharmacokineticsBiopharmaceuticsDrugsMetabolismElectronic books.Pharmacokinetics.Biopharmaceutics.DrugsMetabolism.615.7615/.7Curry Stephen H.96094Whelpton RobinMiAaPQMiAaPQMiAaPQBOOK9910139399403321Drug disposition and pharmacokinetics2074121UNINA