03044nam 2200565 a 450 991013923540332120240313151452.01-118-49808-91-299-24238-31-118-49817-8(CKB)2560000000098550(EBL)1129726(OCoLC)825108262(SSID)ssj0000831870(PQKBManifestationID)11482945(PQKBTitleCode)TC0000831870(PQKBWorkID)10881229(PQKB)10967504(MiAaPQ)EBC1129726(Au-PeEL)EBL1129726(CaPaEBR)ebr10662562(CaONFJC)MIL455488(PPN)182857441(EXLCZ)99256000000009855020130123d2013 uy 0engur|n|---|||||txtccrChemical synthesis of nucleoside analogues /edited by Pedro Merino1st ed.Hoboken, N.J. Wileyc20131 online resource (918 p.)Description based upon print version of record.1-118-00751-4 Includes bibliographical references and index.Deoxynucleoside analogues / Vicente Gotor -- Nucleosides modified at the base moiety / Luigi Agrofoglio -- Acyclic nucleosides / Antonin Holy -- Phosphorylated nucleoside analogues / Giovanni Romeo -- Triphosphorylated nucleoside analogues / Chris Meier -- Pro-nucleotides / Christian Perigaud -- C-nucleoside / Sergio Castillón -- Isonucleosides / Vasu Nair -- Conformationally constrained nucleosides / Jacques Lebreton -- Spironucleosides / Maria Jose Camarasa -- L-nucleosides / Daniela Perrone -- Carbocyclic nucleosides / Eric Leclerc -- Uncommon three-, four, and six-membered nucleosides / Elisabetta Groaz -- Thionucleosides / L.S. Jeong -- Azanucleosides and related compounds / Tomas Tejero -- Oxathiolane and dioxolane nucleosides / Annalisa Guaragna -- Isoxazolidinyl nucleosides / Ugo Chiacchio -- Nucleoside antibiotics / Apurba Dutta -- Building blocks for peptide nucleic acids / Pedro Merino.Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including:Changes to the heterocyclic baseModification of substituents at the sugar ring</lNucleosidesNucleosides.616.9/1061Merino Pedro1962-982269MiAaPQMiAaPQMiAaPQBOOK9910139235403321Chemical synthesis of nucleoside analogues2242017UNINA