05037nam 2200685Ia 450 991013905460332120200520144314.01-118-63548-51-118-63546-91-118-63549-3(CKB)2560000000102101(EBL)1209637(OCoLC)850080840(SSID)ssj0000886414(PQKBManifestationID)11550379(PQKBTitleCode)TC0000886414(PQKBWorkID)10817529(PQKB)11394235(MiAaPQ)EBC1209637(Au-PeEL)EBL1209637(CaPaEBR)ebr10716699(CaONFJC)MIL496231(PPN)204599032(EXLCZ)99256000000010210120130318d2013 uy 0engur|n|---|||||txtccrMuscle disease[electronic resource] pathology and genetics /edited by Hans H. Goebel, Caroline A. Sewry, Roy O. Weller2nd ed.Chichester, West Sussex ;Hoboken, NJ Wiley-Blackwell20131 online resource (986 p.)Description based upon print version of record.0-470-67205-6 Includes bibliographical references and index.Cover; Advisory Editors; Title page; Copyright page; List of Contributors; Preface; List of Abbreviations; 1: Introduction to Muscle Disease: Pathology and Genetics; Introduction; Structure of the book; Conclusion; Section 1: Assessment of Muscle Disease; 2: Clinical Features of Muscle Disease; Introduction; Clinical history and examination; Conclusion; 3: General Pathology of Muscle Disease; Introduction; Selection of muscle to biopsy; Biopsy technique; Tissue preparation; Use of other tissues for diagnosis; Development of human muscleHistological and histochemical features of normal muscleHistological and histochemical defects in pathological muscle; Structural abnormalities; Absence of an enzyme; Storage of a product; Immunohistochemistry; Electron microscopy; Future perspectives; 4: Genetics of Muscle Disease; Introduction; Discovery of genes causing muscle disease; Benefits of finding the mutation causing a disease in a patient; Types of DNA mutations; Blurring of traditional clinical classifications - parallel nosologiesMutations within the same gene can cause a spectrum of phenotypes (as classified by classic nosology)One disease-related pathology can be caused by mutations in different genes; Some genes are to date only implicated in one disease; Some muscle proteins have not yet been associated with human disease; Interesting recent developments; The way forward, addressing the grand challenges in the genetics of muscle disease; Conclusions and future perspectives; Section 2: Neurogenic Muscle Disease; 5: Neurogenic Muscle Pathology; Defining denervation; Clinical features; PathophysiologyPathological changesFetal and infantile denervation; Differential diagnosis; Section 3: Diseases of Neuromuscular Transmission; 6: Autoimmune Myasthenias; Introduction; Incidence; Clinical features; Investigations; Treatment and prognosis; Pathology; Genetics; Differential diagnosis; Animal models; Lambert-Eaton myasthenic syndrome; 7: Congenital Myasthenic Syndromes; Introduction; The neuromuscular junction; Clinical features of congenital myasthenic syndromes; Conclusions and future perspectives; Section 4: Sarcolemma: Muscular Dystrophies and Related Disorders8: Dystrophin and Its Associated Glycoprotein ComplexIntroduction; Incidence; Clinical features; Pathology; Genetics; Animal models; Conclusions and future perspectives; 9: Proteins of the Extracellular Matrix; Introduction; Congenital muscular dystrophies; Laminin α2 primary deficiency; Collagen VI-related myopathies; Perlecan-related disorders; Laminin β2 and agrin-related disorders; Animal models for extracellular matrix-related disorders; Conclusions and future perspectives; 10: Plasma Membrane Proteins: Dysferlin, Caveolin, PTRF/Cavin, Integrin α7, and Integrin α9; IntroductionDysferlinThis book clarifies the pathology and genetics of muscle disease for pathologists, clinicians, geneticists and researchers to aid in the diagnosis and management of patients. Organized around the 'motor unit' concept, this book presents the latest understanding of muscle disease, and how this can help identify new treatments.MusclesDiseasesGeneticsMusclesDiseases.Genetics.616.7/4Goebel H. -H961687Sewry Caroline A769008Weller Roy O961688International Society of Neuropathology.MiAaPQMiAaPQMiAaPQBOOK9910139054603321Muscle disease2180258UNINA