02627nam 2200433 450 991013829220332120230719200446.0953-51-6617-4(CKB)3230000000075341(NjHacI)993230000000075341(oapen)https://directory.doabooks.org/handle/20.500.12854/65386(EXLCZ)99323000000007534120221014d2011 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierAcute Leukemia The Scientist's Perspective and Challenge /edited by Mariastefania AnticaIntechOpen2011Rijeka :InTech,2011.©20111 online resource (xi, 442 pages) illustrations953-307-553-8 Includes bibliographical references.This book provides a comprehensive overview of he basic mechanisms underlying areas of acute leukemia, current advances, and future directions in management of this disease. The first section discusses the classification of acute leukemia, taking into account diagnoses dependent on techniques that are essential, and thankfully readily available, in the laboratory. The second section concerns recent advances in molecular biology, markers, receptors, and signaling molecules responsible for disease progression, diagnostics based on biochips and other molecular genetic analysis. These advances provide clinicians with important understanding and improved decision making towards the most suitable therapy for acute leukemia. Biochemical, structural, and genetic studies may bring a new era of epigenetic based drugs along with additional molecular targets that will form the basis for novel treatment strategies. Later in the book, pediatric acute leukemia is covered, emphasizing that children are not small adults when it comes to drug development. The last section is a collection of chapters about treatment, as chemotherapy-induced toxicity is still a significant clinical concern. The present challenge lies in reducing the frequency and seriousness of adverse effects while maintaining efficacy and avoiding over-treatment of patients.Acute leukemiaAcute leukemiaOncologyAcute leukemia.616.99419Antica Mariastefaniaedt1372056Antica MariastefaniaNjHacINjHaclBOOK9910138292203321Acute Leukemia3401919UNINA