02096nam 2200421 450 991013766540332120231116231033.0953-51-6737-5(CKB)3230000000077059(NjHacI)993230000000077059(oapen)https://directory.doabooks.org/handle/20.500.12854/65521(EXLCZ)99323000000007705920221022d2012 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierSystemic Sclerosis An Update on the Aberrant Immune System and Clinical Features /edited by Timothy RadstakeIntechOpen2012[Place of publication not identified] :InTech,2012.1 online resource (220 pages)953-307-869-3 Includes bibliographical references and index.Systemic sclerosis (SSc), or often referred to as Scleroderma (tight skin), is characterized by an exaggerated formation of collagen fibers in the skin, which leads to fibrosis. Accumulating evidence now points toward three pathological hallmarks that are implicated in Ssc, the order of which has yet to be determined: endothelial dysfunction, autoantibody formation, and activation of fibroblasts. This current book provides up-to-date information on the pathogenesis and clinical features of this severe syndrome. It is our hope that this book will aid both clinicians and researchers in dealing with patients with this clinical syndrome. In addition, we hope to shed more light on this rare and severely disabling syndrome, ultimately leading to better research and successful therapeutic targeting.Systemic sclerosisImmunologyImmunologyImmunology.616.079Radstake Timothyedt1379573Radstake TimothyNjHacINjHaclVIDEO9910137665403321Systemic Sclerosis3419543UNINA