03818nam 2200625 450 991013753320332120230621135619.09782889195657 (ebook)(CKB)3710000000569663(SSID)ssj0001666247(PQKBManifestationID)16455174(PQKBTitleCode)TC0001666247(PQKBWorkID)15000165(PQKB)11743784(WaSeSS)IndRDA00056289(oapen)https://directory.doabooks.org/handle/20.500.12854/42835(EXLCZ)99371000000056966320160829d2015 uy |engur|||||||||||txtccrCD4+ T cell differentiation in infection[electronic resource] amendments to the Th1/Th2 axiom /edited by Dragana Jankovic and Carl G. FengFrontiers Media SA2015France :Frontiers Media SA,20151 online resource (111 pages) colour illustrationsFrontiers Research TopicsBibliographic Level Mode of Issuance: MonographIncludes bibliographical references.CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.Clinical ImmunologyHILCCMedicineHILCCHealth & Biological SciencesHILCCInfectionDendritic CellsCytokinesImmunoregulationCD4 lymphocytesMemorylong noncoding RNAMacrophagesMetabolismTh1 Th2Clinical ImmunologyMedicineHealth & Biological SciencesCarl G Fengauth1366255Feng Carl GJankovic DraganaPQKBUkMaJRU9910137533203321CD4+ T cell differentiation in infection3388739UNINA01755oam 2200457 450 991070621750332120171101085457.0(CKB)5470000002456266(OCoLC)994303552(OCoLC)958933662(EXLCZ)99547000000245626620170724d2002 ua 0engur|||||||||||rdacontentrdamediardacarrierDescription and results of the 2000 NIST/NOAA interlaboratory comparison exercise program for organic contaminants and trace elements in marine mammal tissues /John R. Kucklick [and eight others][Gaithersburg, Maryland] :U.S. Department of Commerce, National Institute of Standards and Technology,2002.1 online resource (vii, 26 pages) illustrationsNISTIR ;6849"July 2002."Electronic version lacks appendices.Includes bibliographical references (pages 25-26)Marine pollutionMeasurementStatisticsWaterPollutionToxicologyStatisticsMarine mammalsEffect of pollution onStatistics.lcgftMarine pollutionMeasurementWaterPollutionToxicologyMarine mammalsEffect of pollution on.Kucklick John R.1390354National Institute of Standards and Technology (U.S.),United States.National Oceanic and Atmospheric Administration.NBSNBSOCLCOGPOBOOK9910706217503321Description and results of the 2000 NIST3516777UNINA02277nam0 22004573i 450 MIL009167920231121125533.0ERR15030394212503039413978250303942819920402d1991 ||||0itac50 balatgerlatbez01i xxxe z01nPascasii Radberti Expositio in Psalmum 44.cura et studio Bedae PaulusTurnholtiTypographi Brepols editores pontificii1991XIV, 125 p., [1]]c. di tav.1 facs.26 cm.Corpus Christianorum. Continuatio Mediaevalis94001CFI00784492001 Corpus Christianorum. Continuatio Mediaevalis94001MIL01080442001 Paschasius RadbertusExpositio in Psalmum 44.CETEDOC, Universitas catholica Lovaniensis Lovanii NoviExpositio in psalmum 44.BVE0842814CFIV0846371852243Expositio in psalmum 44. ((Paschasius Radbertus <santo>MIL0091708223.2Antico Testamento. Salmi.21Paschasius Radbertus <santo>CFIV084637070452699Paulus, BedaCFIV084638Paschase, RadbertBVEV268334Paschasius Radbertus <santo>Pascasius Radbertus <santo>CFIV084660Paschasius Radbertus <santo>ITIT-0119920402IT-RM028 IT-RM0313 IT-RM0281 IT-FR0084 IT-RM0151 IT-FR0017 Biblioteca Universitaria AlessandrinaRM028 BIBLIOTECA CASANATENSERM0313 BIBLIOTECA VALLICELLIANARM0281 Biblioteca Del Monumento Nazionale Di MontecassinoFR0084 Biblioteca Istituto Storico Italiano Medio Evo - IRM0151 Biblioteca umanistica Giorgio ApreaFR0017 MIL0091679Biblioteca umanistica Giorgio Aprea 52CIS C.C.C.M.94 52VM 0000445915 VM barcode:00015030. - Inventario:8661 FLSVMB 2004052420121204 01 07 08 25 41 52Expositio in Psalmum 441852243UNICAS