03322nam 2200481zu 450 991013723990332120210807004915.0(CKB)3710000000506260(SSID)ssj0001683362(PQKBManifestationID)16509606(PQKBTitleCode)TC0001683362(PQKBWorkID)15038063(PQKB)10637832(WaSeSS)IndRDA00056627(oapen)https://directory.doabooks.org/handle/20.500.12854/54488(oapen)doab54488(EXLCZ)99371000000050626020160829d2015 uy engur|||||||||||txtccrNeuroactive metabolites of ethanol : a behavioral and neurochemical synopsisFrontiers Media SA2015[Lausanne, Switzerland] :Frontiers Media SA,20151 online resource (126 pages)Frontiers Research Topics,1664-8714Bibliographic Level Mode of Issuance: Monograph2-88919-375-6 Includes bibliographical references.Ethanol is a very elusive drug, which has mechanisms of action that are diverse and relatively non-selective. Moreover, ethanol has been demonstrated to be a biologically active substance by itself, but also a pro-drug of the neuroactive metabolites, acetaldehyde and acetate. Acetaldehyde has traditionally been known as a toxic substance with several effects on multiple systems. However, in the last few decades evidence has accumulated to reveal the specific and, in some instances, distinct neural actions of acetaldehyde and acetate that are in part responsible for some of the observed psychoactive effects of ethanol. The present issue will address these challenges to provide an up-to-date synopsis of the behavioral and neurophysiological impact of the two direct metabolites of ethanol, acetaldehyde and acetate. In doing so, this issue will present human and rodent evidence on their behavioral and neurophysiological impact, either when administered alone as drugs, or when metabolically-derived from their parent compound. Emphasis will be placed to stress the importance of the different enzymatic systems that intervene to produce these metabolites, either peripherally and/or directly in the brain. Similarly, this Research Topic will be aimed at addressing some of the possible mechanisms of action of acetaldehyde and acetate in different brain areas and in different intracellular systems. Furthermore, the issue will lay out some of the suggested mechanisms of action of ethanol and of its metabolites by which they form adducts with other molecules and neurotransmitters such as dopamine and opioids (which lead to salsolinol and tetrahydropapaveroline, respectively), and their impact on the synthesis and actions of neuromodulators such as adenosine and the cannabinoid system.EthanolEthanol.Elio Acquasauth1287678Salamone J. D(John D.),Acquas ElioCorrea MercèPQKBBOOK9910137239903321Neuroactive metabolites of ethanol : a behavioral and neurochemical synopsis4418168UNINA