03644nam 2200541 450 991013720980332120181023131100.0(CKB)3710000000526071(SSID)ssj0001666216(PQKBManifestationID)16455522(PQKBTitleCode)TC0001666216(PQKBWorkID)15000294(PQKB)10115345(WaSeSS)IndRDA00056201(EXLCZ)99371000000052607120160829d2014 fy 0engurm|#---|||||txtrdacontentcrdamediacrrdacarrierBrain connectivity in autism[electronic resource] /topic editors: Rajesh K. Kana, Lucinda Q. Uddin, Tal Kenet, Diane Chugani and Ralph-Axel Müller[Lausanne, Switzerland] :Frontiers Media SA,20141 online resource (264 pages) illustrations (mostly colour); digital, PDF file(s)Frontiers Research TopicsFrontiers in human neuroscienceBibliographic Level Mode of Issuance: Monograph2-88919-282-2 Includes bibliographical references.The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience will address “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspective.Frontiers in human neuroscience.AutismResearchNeurosciencesNeuroimagingAutismResearch.Neurosciences.NeuroimagingKana Rajesh K.Uddin Lucina Q.Kenet TalChugani DianeMüller Ralph-AxelPQKBUkMaJRUBOOK9910137209803321Brain connectivity in autism1923283UNINA