04116nam 2200625 450 991013720560332120230621140722.09782889192793(ebook)(CKB)3710000000526086(SSID)ssj0001680364(PQKBManifestationID)16496324(PQKBTitleCode)TC0001680364(PQKBWorkID)15028535(PQKB)11675584(WaSeSS)IndRDA00056395(oapen)https://directory.doabooks.org/handle/20.500.12854/53850(EXLCZ)99371000000052608620160829d2015 uy |engurc|#---|||||txtrdacontentcrdamediacrrdacarrierMolecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases /Frontiers Media SA2015France :Frontiers Media SA,20151 online resource (163 pages) illustrations; digital, PDF file(s)Frontiers Research TopicsBibliographic Level Mode of Issuance: MonographIncludes bibliographical references.Cytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, tumorigenic, and otherwise stressed cells. By the virtue of cytokine and chemokine secretion, they can influence other cells of the immune system. Through these processes, cytotoxic lymphocytes also contribute to the maintenance of immune homeostasis. In recent years, much progress has been made with respect to the mechanisms by which cytotoxic lymphocytes develop, differentiate, and exert their effector functions. In a clinical perspective, a wide variety of mutations impairing cytotoxic lymphocyte development and/or function have been associated with immunodeficiency and severe diseases in humans. Aberrant activity of cytotoxic T cells and/or NK cells has been linked to an increased susceptibility to viral infections, persistent inflammation, cancer and autoimmunity. In addition, lymphocyte cytotoxic activity may be harnessed therapeutically to target tumor cells in different adoptive cellular therapy regimes, or through the use of recombinant antibodies. Still, a number of questions remain in regards to how cytotoxic lymphocytes develop, their relationships and plasticity, as well as the mechanisms dictating target cell discrimination, lytic granule release and induction of target cell death. In this Research Topic we encourage submission of research articles, reviews, perspectives, or methods on cytotoxic lymphocyte development and function, their relation to the pathogenesis or treatment of different diseases, as well as comparison between similarities and/or differences in their effector functions. Considering the clinical significance of NK cells and cytotoxic T cells, we aim to provide a range of articles summarizing the current knowledge on the identification and elucidation of the mechanisms governing cytotoxic lymphocyte activity.Microbiology & ImmunologyHILCCBiologyHILCCHealth & Biological SciencesHILCCsecretory lysosomesNK cellshemophagocytic histiocytosisimmune therapygranzymelytic granulesCytotoxicityanti-tumor responseImmunological SynapsePerforinMicrobiology & ImmunologyBiologyHealth & Biological SciencesKonrad Krzewskiauth1364357Krzewski KonradBryceson YenanPQKBUkMaJRU9910137205603321Molecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases3385560UNINA