03529nam 2200637 450 991013720530332120230621140344.09782889193844(ebook)(CKB)3710000000520137(SSID)ssj0001683364(PQKBManifestationID)16509559(PQKBTitleCode)TC0001683364(PQKBWorkID)15037989(PQKB)10499707(WaSeSS)IndRDA00056653(oapen)https://directory.doabooks.org/handle/20.500.12854/54492(EXLCZ)99371000000052013720160829h20152015 fy 0engur||#||||||||txtrdacontentcrdamediacrrdacarrierNeurobiological circuit function and computation of the serotonergic and related systems /Topic editors: Kae Nakamura and KongFatt Wong-LinFrontiers Media SA2015[Lausanne, Switerland] :Frontiers Media SA,[2015]©20151 online resource (165 pages) illustrations (black and white, and colour); digital file(s)Frontiers Research Topics,1664-8714Bibliographic Level Mode of Issuance: Monograph"Published in: Frontiers in integrative neuroscience" -- front cover.Print version: Wong-Lin, KongFatt (editor). Neurobiological circuit function and computation of the serotonergic and related systems. [Lausanne, Switzerland] : Frontiers Media SA, 2015 2889193845 Includes bibliographical references.Serotonin is one of the oldest neurotransmitters in evolutionary terms, and the serotonergic system is complex and multifaceted. Serotonin-producing neurons in the raphe nuclei provide serotonin innervations throughout various parts of the brain, modulating cellular excitability and network properties of targeted brain areas, and regulating mood, cognition and behavior. Dysfunctions of the serotonergic system are implicated in neuropsychiatric disorders including depression, schizophrenia, and drug abuse. Although the system has been studied for many years, an integrative account of its functions and computational principles remains elusive. This is partly attributed to the high variability and heterogeneity in terms of neuronal properties and receptor types, and its extensive connections with other brain regions. This Frontiers Research Topic e-book is a collection of recent experimental and computational work and approaches at multiple scales that provide the latest information regarding the integrated functions of the serotonergic system. The contributed papers include a variety of experimental and computational work, and human clinical studies.Frontiers research topics.SerotoninDopaminedorsal raphe nucleusLocus Coeruleusneural circuitDopamineSerotoninpendunculopontine tegmental nucleusserotonin 5-HTcomputational modelingSerotonin.Dopamine.Kae Nakamuraauth1366028Wong-Lin KongFattNakamura KaePQKBUkMaJRUBOOK9910137205303321Neurobiological circuit function and computation of the serotonergic and related systems3388485UNINA