01653oas 2200541 a 450 991069520750332120170627083536.0(CKB)5470000002368670(OCoLC)53236628(OCoLC)56792673(OCoLC)71364695(OCoLC)810136989(OCoLC)962873798(EXLCZ)99547000000236867020031020b19uu2012 sa engurcn|||||||||txtrdacontentcrdamediacrrdacarrierBackground note, Dominica /Bureau of Western Hemisphere Affairs[Washington, D.C.] U.S. Dept. of State, Bureau of Western Hemisphere Affairs-20121 online resource (volumes)Diplomatic relationsfastPolitics and governmentfastTravelfastDominicaDescription and travelPeriodicalsDominicaForeign relationsPeriodicalsDominicaPolitics and governmentPeriodicalsDominicafastPeriodicals.fastDiplomatic relations.Politics and government.Travel.United States.Department of State.Bureau of Western Hemisphere Affairs.GPOGPOOCLCQGPOOCLCQOCLCAOCLCQOCLCAOCLCFOCLCOOOCLCQGPODOCUMENT9910695207503321Background note, Dominica3115349UNINA02939nam 2200421z- 450 991013709980332120210212(CKB)3710000000824698(oapen)https://directory.doabooks.org/handle/20.500.12854/61171(oapen)doab61171(EXLCZ)99371000000082469820202102d2015 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierTranscellular Cycles Underlying NeurotransmissionFrontiers Media SA20151 online resource (105 p.)Frontiers Research Topics2-88919-654-2 Synaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cerebral activation, neuroglial coupling and the associated neurovascular response. Briefly, exacerbated oxygen consumption in stimulated neurons is thought to trigger glycolytic lactate and glucose transfer from astrocytes which, in turn, obtain these fuels from the microvasculature. Neurotransmitter release is made possible by a combination of transcellular cycles exchanging metabolites between these three compartments, returning eventually the synapsis to its pre-firing situation in the resting periods. In spite of the enormous progresses achieved in recent years, the drivers determining the predominant direction of the fluxes, their quantitative contribution and their energy requirements, have remained until today incompletely understood, more particularly under the circumstances prevailing in vivo. In many instances, progress derived from the implementation of novel methodological approaches including advanced neuroimaging and neurospectroscopy methods. As a consequence, literature in the field became vast, diverse and spread within journals of different specialities. The e-book "Transcellular cycles underlying neurotransmission" aims to summaryze in a single volume, recent progress achieved in hypothesis, methods and interpretations on the trafficking of metabolites between neurons and glial cells, and the associated mechanisms of neurovascular coupling.Neurosciencesbicssc13C NMRAstrocyte-neuron lactate shuttleAstrocytic Networksfunctional MRIglutamate-glutamine cycleNeuroglial metabolic couplingNeuroimagingNeurovascular couplingNeurosciencesSebastian Cerdanauth1328829BOOK9910137099803321Transcellular Cycles Underlying Neurotransmission3039005UNINA