01157nam a2200277 i 4500991003843169707536080806s2006 xxua b 001 0aeng d9780393058635b13760038-39ule_instDip.to Scienze pedagogicheita616.80092Kandel, Eric R.67166In search of memory :the emergence of a new science of mind /Eric R. KandelNew York :W.W. Norton & Co.,cop. 2006xv, 510 p. :ill. ;24 cmBibliografia: p. 453-484Kandel, Eric R.,1929-BiografiaMemoriaNeurobiologia.b1376003804-05-0906-08-08991003843169707536LE022 616 KAN01.0112022000126656le022LE022/SALVATORE/2008pE35.00-ns 00000.i1482463210-09-08LE022 616 KAN01.01 C.0212022000128551le022LE022/MONOGRAFIE/2009LE022/SALVATORE/2009pE16.00-ns 00000.i1496253604-05-09In search of memory1228432UNISALENTOle02206-08-08ma -engxxu0003461oam 2200505 450 991013709870332120230807212008.0(CKB)3710000000824702(oapen)https://directory.doabooks.org/handle/20.500.12854/43471(EXLCZ)99371000000082470220160822h20152015 fy 0engurmn#---|||||txtrdacontentcrdamediacrrdacarrierCognitive deficits in schizophrenia and other neuropsychiatric disorders[electronic resource] convergence of preclinical and clinical evidence /edited by Ales Stuchlik and Tomiki SumiyoshiFrontiers Media SA2015Lausanne, Switzerland :Frontiers Media SA,2015.©20151 online resource (283 pages) illustrations, charts; digital, PDF file(s)Frontiers research topicsPublished in Frontiers in Behavioral Neuroscience.2-88919-679-8 Includes bibliographical references.Neuropsychiatric disorders such as schizophrenia, extrapyramidal disorders, Alzheimer's disease and other unrelated dementias, represent a serious human, medical and socioeconomic burden. These diseases are often accompanied by impairments of cognitive function, e.g., thinking, decision-making, and learning and memory. Such deficits significantly worsen quality of life and daily functioning of afflicted patients. Cognitive deficits in schizophrenia and other psychiatric diseases are associated with alterations of brain morphology and function, which are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, measurable phenotypes linking these complex disorders with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Experimental animal models may not mimic the full spectrum of clinical symptoms, but may work as analogies of particular behaviors or other disease manifestations. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, there is accumulated evidence showing (sometimes highly specific) deficits in cognition in these animal models of neuropsychiatric disorders. Moreover, there are a series of sensitive tests to measure cognitive performance in rodents and other species. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of central nervous system (CNS) disorders, and delineate future directions for translational studies aimed at developing novel treatments/interventions of these disturbances, both at clinical and preclinical levels.NeuroscienceLearningNeurologycognitive deficitsMemoryneuropsychiatric disordersCognitiontranslation researchanimal modelPsychiatryNeuroscience.Ales Stuchlikauth1374730Stuchlik AlesSumiyoshi TomikiUkMaJRUBOOK9910137098703321Cognitive deficits in schizophrenia and other neuropsychiatric disorders3408233UNINA