03986oam 2200613 450 991013708830332120230621140048.09782889196449(CKB)3710000000824754(oapen)https://directory.doabooks.org/handle/20.500.12854/40472(EXLCZ)99371000000082475420191103h20152015 fy| 0engurcn#---||||ntxtrdacontentcrdamediacrrdacarrierAging, neurogenesis and neuroinflammation in hearing loss and protection /Marta Magariños, Marta Milo and Isabel Varela-NietoFrontiers Media SA2015[Lausanne, Switzerland] :Frontiers Media SA,[2015]©20151 online resource (151 pages) illustrations (chiefly colour); digital file(s)Frontiers Research TopicsPrint version: 2889196445 Includes bibliographical references.Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies.There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease.In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes involved in ageing as senescence and autophagy, to molecules essential for hearing as IGF-1 and neurotrophins. Neuroinflammation takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Neurogenesis is also essential to understand the adult cochlea self-repair potential. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies.Frontiers research topics.PresbycusisVestibular apparatusDeafnessEtiologyDeafnessTreatmentTGF-betaNoiseHair cellsredox balancespiral ganglion neuronsDrug deliveryARHLAuditory CortexLipid homeostasisInner earPresbycusis.Vestibular apparatus.DeafnessEtiology.DeafnessTreatment.617.8Marta Magarinosauth1366880Magariños MartaMilo MartaVarela-Nieto IsabelUkMaJRU9910137088303321Aging, neurogenesis and neuroinflammation in hearing loss and protection3389399UNINA