02874nam 2200505 450 991013679900332120230621140740.0(CKB)3710000000631132(oapen)https://directory.doabooks.org/handle/20.500.12854/40966(EXLCZ)99371000000063113220160411d2015uuuu fy| 0engurcu#---uuuuutxtrdacontentcrdamediacrrdacarrierAntimicrobial peptides and Complement - maximising the inflammatory response[electronic resource] /edited by: Cordula M. StoverFrontiers Media SA2015[Lausanne, Switzerland] :Frontiers Media SA,2015.1 online resource (157 pages) illustrations; digital, PDF file(s)Frontiers research topicsFrontiers in Immunology2-88919-737-9 Includes bibliographical references.Antimicrobial peptides and complement are distinct components of the innate immune defence. While antimicrobial peptides, after cleavage of a preproprotein, have the ability to insert directly in non host membranes, complement requires a sequential enzymatic activation in the fluid phase in order to produce a transmembrane membrane attack complex. Its insertion is controlled by membrane bound regulators. Deficiencies are described for both effectors and relate to increased susceptibility of infection. In addition, however, antimicrobial peptides and complement each influence the activity of inflammatory cells as recent data in the respective research areas shows. This series of articles draws together for the entities of antimicrobial peptides and complement a balance of contributions in the areas of evolution, roles, functions and preclinical applications. By comparing and contrasting antimicrobial peptides and complement, greater cross-disciplinary appreciation will be derived for their individual and overlapping spectra of activity, circumstances of activation and their general ability to more completely inform the inflammatory and cellular response.Frontiers in Immunology.ImmunologyPeptide antibioticsComplement System ProteinsimmunologyDiseaseregulationHealthsystem-specificcomplementantimicrobial peptidesImmunology.Peptide antibiotics.Complement System Proteinsimmunology.Cordula M. Stoverauth1364628Stover Cordula M.UkMaJRUBOOK9910136799003321Antimicrobial peptides and Complement - maximising the inflammatory response3386067UNINA