01273nam0 22002771i 450 UON0037930120231205104519.51788-14-15317-520100319d2010 |0itac50 baitaIT|||| |||||ˆIl ‰trattato di Lisbonache modifica il Trattato sull'Unione Europea e il Trattato della Comunità Europeaversione ragioanata e sistematica per un consultazione coordinata degli articoli alla luce dei Protocolli e delle DichiarazioniMassimo FragolaMilanoGiuffré2010X, 393 p.24 cm.001UON002549742001 Università degli Studi della Calabria. Dipartimento di Scienze Giuridiche - Area Giuspubblicistica.26Trattato di LisbonaUONC069630FIITMilanoUONL000005FragolaMassimoUONV14261534323GiuffrèUONV257275650ITSOL20250207RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00379301SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI COM 2.0 0005 SI SC 46281 5 0005 BuonoTrattato di Lisbona776098UNIOR02477nam 2200469z- 450 991013679790332120210212(CKB)3710000000631143(oapen)https://directory.doabooks.org/handle/20.500.12854/58575(oapen)doab58575(EXLCZ)99371000000063114320202102d2016 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of ToleranceFrontiers Media SA20161 online resource (107 p.)Frontiers Research Topics2-88919-770-0 The focus of this eBook is to bring new insights into central immune tolerance. To fulfill that, much has been discussed about the master in the regulation of tolerance, the autoimmune regulator (Aire) gene the main thymus cell type that expresses this gene, the medullary thymic epithelial cells (mTECs). It includes one Editorial and 12 other excellent contributions in the format of mini reviews or original research papers covering one or more of these aspects: promiscuous gene expression (PGE), epigenetics, miRNAs, association of the Aire gene and miRNAs, thymocyte-TEC interaction, coxsackievirus and type 1 diabetes, exosomes in the thymus, thymic crosstalk, thymic B cells, T cell development, chemokines and migration of T cells, miRNAs and the thymic atrophy, cell-cell interactions, and thymus ontogeny. Authors raised hypothesis, discuss concepts, and show open questions. The remaining important issues to resolve questions within the central tolerance research are briefly discussed below.MedicinebicsscAire genecell-cell interactionCentral ToleranceChemokinesmicroRNApromiscuous gene expressionThymic B cellthymic crosstalkthymocyteThymusMedicineGeraldo Aleixo Passosauth1279442Ernna Herida OliveiraauthDaniella Areas Mendes-da-CruzauthBOOK9910136797903321The Role of Aire, microRNAs and Cell-Cell Interactions on Thymic Architecture and Induction of Tolerance3015381UNINA