01870nam 2200493 450 991070381720332120150811153254.0(CKB)5470000002435563(OCoLC)917654929(EXLCZ)99547000000243556320150811j201504 ua 0engurcn|||||||||txtrdacontentcrdamediacrrdacarrierAtmospheric mining in the outer solar system resource capturing, exploration, and exploitation /Bryan PalaszewskiCleveland, Ohio :National Aeronautics and Space Administration, Glenn Research Center,April 2015.1 online resource (30 pages) color illustrations, mapsNASA/TM ;2015-218096Title from title screen (viewed Aug. 11, 2015)."April 2015.""Prepared for the 49th Joint Propulsion Conference and Exhibit cosponsored by the AIAA, ASME, SAE, and ASEE, San Jose, California, July 14-17, 2013."Includes bibliographical references (pages 29-30).Atmospheric mining in the outer solar system Fuel productionnasatHydrogen 4nasatPlanetary atmospheresnasatSolar systemnasatGas giant planetsnasatFuel production.Hydrogen 4.Planetary atmospheres.Solar system.Gas giant planets.Palaszewski Bryan Alan Richard1388221NASA Glenn Research Center,United States.National Aeronautics and Space Administration,GPOGPOBOOK9910703817203321Atmospheric mining in the outer solar system3457622UNINA03837nam 2200445z- 450 991013679380332120210212(CKB)3710000000631050(oapen)https://directory.doabooks.org/handle/20.500.12854/60979(oapen)doab60979(EXLCZ)99371000000063105020202102d2015 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierToll-Like Receptor Activation in Immunity vs. ToleranceFrontiers Media SA20151 online resource (75 p.)Frontiers Research Topics2-88919-636-4 The innate immune system has evolved means to recognize and react suitably to foreign entities such as infectious agents. In many cases infectious microorganisms threaten the integrity and function of the target organs or tissues; therefore, consequent to their recognition the immune system becomes activated to ensure their elimination. Toll-like receptors (TLR) constitute a family of receptors specialized in the recognition of molecular patterns typically associated with infectious agents. Different TLRs exist, each selective for molecular entities and motifs belonging to a specific pathogen group. Consequently, it is thought that the molecular nature of invading microorganisms activates specific TLRs to drive adequate anti-infectious immunity. For instance, nucleic acid-specific, intracellular receptors (TLR3/7/8/9) are used to sense viruses and drive antiviral immunity, while other receptors (such as TLR2 and TLR4) recognize and promote immunity against bacteria, yeast, and fungi. Yet, it is becoming evident that activation of TLR pathways trigger mechanisms that not only stimulate but also regulate the immune system. For instance, TLR stimulation by viruses will drive antiviral interferon but also immunoregulatory cytokine production and regulatory T cell activation. Stimulation of TLRs by bacteria or using molecular agonists can also trigger both immune stimulatory and regulatory responses. TLR stimulation by infectious agents likely serves to activate but also control anti-infectious immunity, for instance prevent potential immunopathological tissue damage which can be caused by acute immune defense mechanisms. Previous work by us and others has shown that the immunoregulatory arm of TLR stimulation can additionally help control autoreactive processes in autoimmune disease. Hence, it is becoming established that gut commensals, which also play a crucial part in the control of autoimmune disease, establish immune regulatory mechanisms through activation of particular TLRs. In sum, it appears that TLRs are key immune players that not only stimulate but also regulate immune processes in health and disease. In this Research Topic, we wish to review the dual role of TLRs as activators and regulators of immune responses. We aim to motivate data-driven opinions as to the importance of context of TLR agonism for determining immune activation vs. regulation. The presentation of ongoing original works, as well as data and opinions around other innate immune receptors pertaining to this topic, are also encouraged.MedicinebicsscAutoimmune Diseasescancer immunotherapyImmune stimulationImmunoregulationInfectionInflammationmicrobiomeProbioticstoleranceToll-Like ReceptorsMedicineChristophe M. Filippiauth1297628BOOK9910136793803321Toll-Like Receptor Activation in Immunity vs. Tolerance3024636UNINA