04390nam 2200517 450 991013675580332120170919175217.03-527-69394-73-527-69393-93-527-69396-3(CKB)3710000000686072(EBL)4529698(MiAaPQ)EBC4529698(EXLCZ)99371000000068607220160531h20162016 uy 0gerur|n|---|||||rdacontentrdamediardacarrierBioactive carboxylic compound classes pharmaceuticals and agrochemicals /edited by Clemens Lamberth and Jürgen DingesWeinheim, Germany :Wiley-VCH Verlag,2016.©20161 online resource (529 p.)Description based upon print version of record.3-527-33947-7 Includes bibliographical references at the end of each chapters and index.Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Chapter 1 Different Roles of Carboxylic Functions in Pharmaceuticals and Agrochemicals; 1.1 Introduction; 1.2 Solubilizer; 1.3 Pharmacophore; 1.4 Prodrug; 1.5 Bioisosteric Replacement; 1.6 Scaffold; 1.7 Conclusion; References; Part I Neurology; Chapter 2 Carboxylic Ester Containing Norepinephrine-Dopamine Reuptake Inhibitors (NDRIs); 2.1 Introduction; 2.2 History; 2.3 Synthesis; 2.4 Mode of Action; 2.5 Structure-Activity Relationships; References; Chapter 3 Analgesic and Anesthetic Amides; 3.1 Introduction; 3.2 History3.3 Synthesis3.4 Mode of Action; 3.5 Structure-Activity Relationships; References; Part II Cardiovascular Diseases; Chapter 4 Fibrate Acids and Esters for the Treatment of Hyperlipidemia (PPARa Activators); 4.1 Introduction; 4.2 History; 4.3 Synthesis; 4.4 Mode of Action; 4.5 Structure-Activity Relationships; References; Chapter 5 Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events; 5.1 Introduction; 5.2 History; 5.3 Synthesis; 5.4 Mode of Action; 5.5 Structure-Activity Relationships; ReferencesChapter 6 Carboxylic Acids and Lactones as HMG-CoA Reductase Inhibitors6.1 Introduction; 6.2 History; 6.3 Synthesis; 6.4 Mode of Action; 6.5 Structure-Activity Relationship; References; Chapter 7 Angiotensin II Receptor Antagonists with Carboxylic Functionalities in Cardiovascular Disease; 7.1 Introduction; 7.2 History; 7.3 Synthesis; 7.4 Mode of Action; 7.5 Structure-Activity Relationships; References; Chapter 8 Carboxylic Acid Containing Direct Thrombin Inhibitors for the Treatment of Thromboembolic Diseases; 8.1 Introduction; 8.2 History; 8.3 Synthesis; 8.4 Mode of Action8.5 Structure-Activity RelationshipReferences; Part III Infectious Diseases; Chapter 9 Tetracycline Amide Antibiotics; 9.1 Introduction; 9.2 History; 9.2.1 First-Generation Tetracyclines - The Discovery; 9.2.2 Second-Generation Semisynthetic Tetracyclines; 9.2.3 Tetracycline Resistance; 9.2.4 Third-Generation Tetracyclines; 9.3 Synthesis; 9.4 Mode of Action; 9.5 Structure-Activity Relationships; References; Chapter 10 Carboxylic-Acid-Based Neuraminidase Inhibitors; 10.1 Introduction; 10.2 History; 10.3 Synthesis; 10.4 Mode of Action; 10.5 Structure-Activity Relationships; ReferencesChapter 11 Oxazolidinone Amide Antibiotics11.1 Introduction; 11.2 History; 11.3 Synthesis; 11.4 Mechanism of Action; 11.5 Structure-Activity Relationships; References; Chapter 12 Sovaldi, an NS5B RNA Polymerase-Inhibiting Carboxylic Acid Ester Used for the Treatment of Hepatitis C Infection; 12.1 Introduction; 12.2 History; 12.3 Synthesis; 12.4 Mode of Action; 12.5 Structure-Activity Relationships; References; Part IV Metabolic Diseases; Chapter 13 Dipeptidyl Peptidase-4 (DPP-4)-Inhibiting Amides for the Treatment of Diabetes; 13.1 Introduction; 13.2 History; 13.3 Synthesis13.4 Mode of ActionAgricultural chemicalsElectronic books.Agricultural chemicals.630.24Lamberth ClemensDinges JürgenMiAaPQMiAaPQMiAaPQBOOK9910136755803321Bioactive carboxylic compound classes2019471UNINA