05161nam 2200757 450 991013645960332120200520144314.03-527-68241-43-527-68238-43-527-68239-2(CKB)3710000000616923(EBL)4451995(OCoLC)945612679(SSID)ssj0001682976(PQKBManifestationID)16508198(PQKBTitleCode)TC0001682976(PQKBWorkID)15037296(PQKB)11729952(MiAaPQ)EBC4451995(Au-PeEL)EBL4451995(CaPaEBR)ebr11174384(CaONFJC)MIL909458(PPN)194624633(EXLCZ)99371000000061692320160326h20162016 uy| 0engur|n|---|||||txtccrHost - pathogen interaction microbial metabolism, pathogenicity and antiinfectives /edited by Gottfried Unden, Eckhard Thines, and Anja SchüfflerWeinheim, Germany :Wiley-VCH Verlag GmbH & Company KGaA,2016.©20161 online resource (237 pages.)Drug discovery in infectious diseasesDescription based upon print version of record.3-527-33745-8 Includes bibliographical references and index.Cover; Title Page; Copyright; Contents; Preface; Cover Legend; List of Contributors; Part One Adaptation of Microbial Metabolism in Host/Pathogen Interaction; Chapter 1 Metabolic Adaptation of Human Pathogenic Yersiniae; Introduction; Yersinia Life Cycles and Pathogenesis; Carbon Metabolism and Links to Yersinia Pathogenesis; Food Sources, Nutrient Sequestration, and Utilization; Metabolic Pathways of Yersinia Crucial for Virulence; Nutritional Virulence: Nutritional Adaptation Important for Pathogenesis; Coordinated Control of Carbon Metabolism and Virulence; Importance of IonsImportance of the Csr SystemImportance of CCR and the cAMP-Crp Complex; Importance of Posttranscriptional Regulation Strategies; Conclusions; Acknowledgments; References; Chapter 2 Crosstalk between Metabolism and Virulence of Legionella pneumophila; Introduction; Key Metabolic Features of L. pneumophila; Serine and Glucose Metabolism of L. pneumophila under In Vitro Conditions; Metabolism of L. pneumophila under Intracellular Conditions; Metabolic Adaptation during the Life Cycle of Intracellular L. pneumophila; Metabolic Host Cell Responses Triggered by Intracellular L. pneumophilaConclusionReferences; Chapter 3 Metabolism of Intracellular Salmonella enterica; Introduction; S. enterica-A Metabolic Generalist; Metabolism of Glucose by S. enterica; Connection to the TCA Cycle by Oxidative Decarboxylation of Pyruvate; The Important Role of the TCA Cycle and Anaplerotic Reactions; Metabolism of Intracellular S. enterica; The Metabolism of S. enterica Compared to Other Important Intracellular and Gastrointestinal Pathogens; Salmonella Induce Networks of Tubular Structures-Access to Host-Derived Nutrients?; S. enterica Has a Bimodal Lifestyle in Epithelial CellsSalmonella Metabolism Limits Possibilities for New AntimicrobialsConclusions; References; Chapter 4 The Human Microbiome in Health and Disease; Introduction; Methods for Characterizing the Microbiota; Diet and Geographical Factors; Functional Gastrointestinal Disorders; Manipulation of the Microbiota; Conclusions; Acknowledgments; References; Chapter 5 Mechanisms of Dysbiosis in the Inflamed Gut; Introduction; Dysbiosis during Inflammatory Diseases of the Gastrointestinal Tract; Nutrient Acquisition by Commensal Bacteria in the Normal GutNutritional Mechanisms for Dysbiosis in the Inflamed GutInflammation-Driven Bloom of Enteric Pathogens in the Gut Lumen; How Anaerobic Respiration Enhances Growth in the Inflamed Gut; Conclusions; References; Chapter 6 Strategies for Nutrient Acquisition by Magnaporthe oryzae during the Infection of Rice; Introduction; Adhesion and Germination; Appressorium Formation; Penetration; Growth in Planta: The Biotrophic Growth Phase; Growth in Planta: Necrotrophic Growth Phase; Growth in Planta: Sporulation; Life Outside of the Rice Plant; Conclusion; ReferencesPart Two New Inhibitors and Targets of Infectious DiseasesDrug discovery in infectious diseases.Host-parasite relationshipsCommunicable diseasesInfectionPathogenic microorganismsAnti-infective agentsHost-parasite relationships.Communicable diseases.Infection.Pathogenic microorganisms.Anti-infective agents.577.857Unden GottfriedThines EckhardSchüffler AnjaMiAaPQMiAaPQMiAaPQBOOK9910136459603321Host - pathogen interaction2221645UNINA