03059nam 2200601 450 991013640150332120230621141323.0(CKB)3710000000612076(oapen)https://directory.doabooks.org/handle/20.500.12854/54512(EXLCZ)99371000000061207620160314h20152015 fy| 0engur||#---|||||txtrdacontentcrdamediacrrdacarrierNeuronal and glial structural plasticity induced by drugs of abuse /edited by: M. Foster Olive and Justin GassFrontiers Media SA2015[Lausanne, Switzerland] :Frontiers Media SA,2015.©20151 online resource (90 pages) illustrations ( some colour); digital file(s)Frontiers Research TopicsFrontiers in Pharmacology2-88919-598-8 Includes bibliographical references.Drugs of abuse induce a host of alterations in brain structure and function, ranging from changes in gene expression and epigenetic processes to aberrant synaptic plasticity to volumetric changes in discrete brain regions. These alterations can be drug class-specific, and are not confined to neurons, as drugs of abuse also induce molecular and cellular alterations in various glial cell types such as astrocytes and microglia. This drug-induced "rewiring" of the brain at numerous levels can contribute to the development, maintenance, and persistence of the addicted state, as well as associated deficits in normal cognitive functioning. The aim of this Research Topic is to collect recent and important findings related to the structural alterations produced by drug of abuse in neurons, glial, and other cell types of the central nervous system. Suitable areas of analysis include but are not limited to: macrostructure of individual brain regions, dendritic branching and architecture, dendritic spine density and morphology, cell soma morphology, presynaptic terminal volume, astrocytic process length and branching, myelination, and microglial phenotype.Frontiers research topics.Frontiers in pharmacology.BrainEffect of drugs onNeuroplasticityNeuropharmacologyResearchDopamineNeuronAddictionSpineGABAplasticityGlutamategliaastrocyteDendriteBrainEffect of drugs on.Neuroplasticity.NeuropharmacologyResearch.M Foster Oliveauth1366715Olive M. FosterGass Justin T.Frontiers Research Foundation,UkMaJRUBOOK9910136401503321Neuronal and glial structural plasticity induced by drugs of abuse3389321UNINA