04439nam 2200793 450 991013628240332120230621140353.0(CKB)3710000000586905(SSID)ssj0001683368(PQKBManifestationID)16509480(PQKBTitleCode)TC0001683368(PQKBWorkID)15037880(PQKB)11451535(WaSeSS)IndRDA00056647(oapen)https://directory.doabooks.org/handle/20.500.12854/54513(EXLCZ)99371000000058690520160829h20142014 uy 0engur||#---|||||txtrdacontentcrdamediacrrdacarrierNeuronal and psychological underpinnings of pathological gambling /topic editors: Bryan F. Singer, Patrick Anselme, Mike J. F. Robinson and Paul VezinaFrontiers Media SA2014[Lausanne, Switzerland] :Frontiers Media SA,2014.1 online resource (132 pages) illustrations; digital file(s)Frontiers Research TopicsFrontiers in Behavioral NeuroscienceBibliographic Level Mode of Issuance: Monograph2-88919-320-9 Includes bibliographical references.Although pathological gambling is a prevalent disease, its neurobiological and psychological underpinnings are not well characterized. Various lines of research suggest aberrant dopaminergic function may lead to pathological gambling. For example, human imaging studies have revealed dopaminergic activation coinciding with the performance of gambling-related tasks. Furthermore, dopamine D2-type receptor deficiency facilitates gambling behaviors and dopamine receptor agonist treatments for Parkinson’s disease have been shown to increase patient vulnerability to gambling. Pathological gambling is often co-morbid with drug addictions, and exposure to drugs of abuse has been shown to enhance motivation to gamble. The activation of midbrain dopamine neurons, as well as their terminal projection fields, is involved with the development and maintenance of various addictions. Importantly, recent articles have demonstrated that repeated exposure to conditions of gambling-like uncertain reinforcement lead to enhanced drive to seek reward, potentially through increasing the incentive motivational value of conditioned cues. Signaling molecules other than dopamine may also influence reward-seeking behaviors in pathological gamblers. For example, stress-related alterations in glucocorticoid signaling may effect decision making and influence gambling behavior. Together, these findings suggest common pathways exist that mediate gambling, drug dependence, stress, and movement disorders, and that cross-reactivity between these ailments may potentiate disease symptomology. The goal of this Research Topic is to further our understanding of the neurobiological mechanisms underlying the development of pathological gambling.Frontiers research topics.Frontiers in behavioral neuroscience.DopaminePathophysiologyDopaminePhysiological effectCompulsive behaviorPathophysiologyCompulsive gamblingEtiologyNeuropsychologyAnimal BiochemistryHILCCHuman Anatomy & PhysiologyHILCCHealth & Biological SciencesHILCCstressGamblingDopamineAddictionventral striatumRewardConditioninguncertaintyDopaminePathophysiology.DopaminePhysiological effect.Compulsive behaviorPathophysiology.Compulsive gamblingEtiology.Neuropsychology.Animal BiochemistryHuman Anatomy & PhysiologyHealth & Biological SciencesPatrick Anselmeauth1364021Singer Bryan FAnselme PatrickRobinson Mike J. F.Vezina PaulPQKBUkMaJRUBOOK9910136282403321Neuronal and psychological underpinnings of pathological gambling3385189UNINA