03129oam 2200553I 450 991013612910332120230810001147.01-315-45405-X1-315-45404-11-315-45403-310.4324/9781315454054 (CKB)3710000000912460(MiAaPQ)EBC4717809(OCoLC)960902227(BIP)56988484(BIP)55357494(EXLCZ)99371000000091246020180706e20171980 uy 0engurcnu||||||||rdacontentrdamediardacarrierAddiction and brain damage /edited by derek RichterAbingdon, Oxon :Routledge,2017.1 online resource (308 pages) illustrationsRoutledge Library Editions: Addictions ;Volume 3First published in 1980 by Croom Helm Ltd.1-138-21088-9 Includes bibliographical references at the end of each chapters and index.pt. 1. Biochemical and physiological mechanisms -- pt. 2. Clinical investigations.Originally published in 1980, recent research had produced new insights into how, at the biochemical level, alcohol and other drugs of abuse can impair metabolic and neuropsychiatric functions. Epidemiological studies were also demonstrating that even moderate drinking or drug abuse can produce significant brain damage. This book draws together the latest biochemical, physiological and clinical research on these topics at the time. The initial chapters discuss how alcohol can interfere with various functions: the adaptability of metabolic processes as governed by the ability of the liver to synthesise new enzymes, cell membrane transport, nervous transmission and the transport of nutrients into the brain. It is suggested that opiates, and possibly alcohol, may affect the endorphin system by blocking the uptake of specific amino acids. The second half of the book reports clinical investigations using biochemical studies, psychological tests, EEG investigations and Computerised Axial Tomography (CAT) scanning. It gives the first report of a long-term study by Lishman and co-workers using an improved tomography technique to assess brain damage in alcoholics. These studies give convincing evidence that heavy drinking, even at socially-acceptable levels, can cause serious brain damage in vulnerable people.AlcoholPhysiological effectCongressesPsychotropic drugsPhysiological effectCongressesBrain damageEtiologyCongressesNeuropharmacologyCongressesAlcoholPhysiological effectPsychotropic drugsPhysiological effectBrain damageEtiologyNeuropharmacology616.86/3Richter derek97914MiAaPQMiAaPQMiAaPQBOOK9910136129103321Addiction and brain damage2201232UNINA