05364nam 2200637Ia 450 991014249350332120170815114948.01-280-27011-X97866102701180-470-31452-40-470-85481-20-470-85482-0(CKB)111056485599104(EBL)141614(OCoLC)53831952(SSID)ssj0000215062(PQKBManifestationID)11201993(PQKBTitleCode)TC0000215062(PQKBWorkID)10167455(PQKB)11534882(MiAaPQ)EBC141614(EXLCZ)9911105648559910420020529d2002 uy 0engur|n|---|||||txtccrOn-line LC-NMR and related techniques[electronic resource] /edited by Klaus AlbertNew York J. Wiley & Sonsc20021 online resource (308 p.)Description based upon print version of record.0-471-49649-9 Includes bibliographical references and index.On-Line LC-NMR and Related Techniques; Contents; Contributors; Preface; 1 LC-NMR: Theory and Experiment; 1.1 Introduction; 1.2 NMR in a Flowing Liquid; 1.3 Design of Continuous-Flow NMR Probes; 1.4 Experimental Arrangement for HPLC-(1)H NMR Coupling; 1.5 Practical Considerations, Solvent Suppression Techniques, Gradient Elution and Purity of HPLC Solvents; 1.5.1 Solvent Signal Suppression; 1.5.2 Purity of HPLC-Grade Solvents; References; 2 LC-NMR: Automation; 2.1 Practical Use of LC-NMR and LC-NMR/MS; 2.2 Different Working Modes in LC-NMR; 2.2.1 On-Flow; 2.2.2 Direct Stop-Flow2.2.3 Loop Storage/Loop Transfer2.2.4 Conclusions; 2.3 Use of Mass Spectrometry in the Set-Up; 2.4 Measurement Procedures; 2.4.1 Sample Preparation and Introduction ('Injection') into the Chromatography System; 2.4.2 Chromatographic Separation; 2.4.3 Peak Detection and Selection; 2.4.4 Mass Spectrometric Measurements; 2.4.5 Nuclear Magnetic Resonance Measurements; 2.4.6 Sample Recovery; 2.5 Conclusions; References; 3 Biomedical and Pharmaceutical Applications of HPLC-NMR and HPLC-NMR-MS; 3.1 Introduction; 3.2 Technical and Operational Overview; 3.3 Applications in Combinatorial Chemistry3.4 Application to Chemical Impurities3.5 Application to Chiral Separations of Pharmaceutical Mixtures; 3.6 Application to Natural Products; 3.7 Application to Chemical Reactivity of Drug Glucuronides; 3.8 Application to Futile Deacetylation Reactions; 3.9 Application to Trapping of Reactive Intermediates; 3.10 Application to Uptake and Transformation of Xenobiotics by Plants; 3.11 Separation of Lipoproteins and their Characterisation using HPLC-NMR; 3.12 Superheated-Water HPLC-NMR and HPLC-NMR-MS Studies on Pharmaceuticals3.13 Application of Hypernation to a Mixture of Non-Steroidal Anti-Inflammatory Drugs3.14 Concluding Remarks; References; 4 Application of On-Line LC-NMR and Related Techniques to Drug Metabolism Studies; 4.1 Introduction; 4.2 LC-NMR Techniques; 4.2.1 Continuous-Flow LC-NMR; 4.2.2 Time-Slice LC-NMR; 4.2.3 Stop-Flow LC-NMR; 4.2.4 Loop-Storage; 4.2.5 LC-NMR-MS; 4.3 Application of LC-NMR-MS to Drug Metabolism: The Structure Elucidation of Rat Urinary Metabolites of Efavirenz by LC-NMR-MS; 4.3.1 Experimental; 4.3.2 Results; 4.4 Conclusions; References; 5 LC-NMR for Natural Products Analysis5.1 Application of LC-NMR and LC-NMR-MS Hyphenation to Natural Products Analysis5.1.1 Introduction; 5.1.1.1 General Aspects; 5.1.1.2 Applications; 5.1.2 Application of LC-NMR-MS to Glycosidic Natural Products of Marine Origin; 5.1.2.1 Introduction - Need for LC-NMR; 5.1.2.2 Methodology: On-Flow LC-NMR-MS Screening; 5.1.2.3 NMR - Structural Information; 5.1.2.4 Mass Spectrometry and D-H Back-Exchange Experiments; 5.1.2.5 Stop-Flow Experiments; 5.1.2.6 Complimentary Structural Information of NMR and MS; 5.1.2.7 Conclusions; 5.1.3 Acknowledgements; References5.2 Hyphenation of Modern Extraction Techniques to LC-NMR for the Analysis of Geometrical Carotenoid Isomers in Functional Food and Biological TissuesThis book gives a comprehensive overview of the basis and the current applications of LC-NMR and related techniques. It deals with the practical aspects of the hardware and software set-up for a successful performance of on-line coupling experiments. It covers the solution of real-word problems from the fields of biomedical, pharmaceutical and environmental studies as well as the analysis of natural products and polymeric compounds. Thus guidelines for an efficient application of the powerful hyphenated technique LC-NMR in combination with LC-MS are presented. Besides LC-NMR, important techniqNuclear magnetic resonance spectroscopyLiquid chromatographyElectronic books.Nuclear magnetic resonance spectroscopy.Liquid chromatography.543.089543/.0877Albert Klaus884205MiAaPQMiAaPQMiAaPQBOOK9910142493503321On-line LC-NMR and related techniques1974475UNINA02824oas 2201021 a 450 991013585310332120251106213014.01545-701X(DE-599)ZDB2066163-0(OCoLC)49882921(CONSER) 2003213730(CKB)954925392317(EXLCZ)9995492539231720020529a19579999 sy aengurmnu||||||||txtrdacontentcrdamediacrrdacarrierComparative education reviewNew York Comparative Education Society1957-1 online resourceRefereed/Peer-reviewedTitle from title screen (JSTOR, viewed July 14, 2004).Imprint varies; published by: Comparative and International Education Society, 1970-1979; published: Chicago, Ill. : University of Chicago Press, 1980-0010-4086 EducationPeriodicalsComparative educationPeriodicalsÉducationPériodiquesÉducation comparéePériodiquesComparative educationfast(OCoLC)fst00871331Educationfast(OCoLC)fst00902499OnderwijskundegttEducacióRevisteslemacEducació comparadaRevisteslemacEducationPeriodicalsnliComparative educationPeriodicalsnliCzasopismo pedagogiczne.dbnPeriodicals.fastPeriodicals.lcgftEducationComparative educationÉducationÉducation comparéeComparative education.Education.Onderwijskunde.EducacióEducació comparadaEducationComparative education370Comparative Education Society,Comparative and International Education Society,TXHTXHOCLCQNSDOCLCQEYMOCLCQWEAOCLCQOCLCFOCLCOOCLCQOCLCEFJMNLCOCLCQU3WVT2NJTRDFSFBOCLCQUBYOCLCOOCLCQUABCUSDLCOCLCLOCLCQJOURNAL9910135853103321Comparative education review977753UNINA