00758nam0-2200277 --450 991056590110332120220516081138.0978-88-572-4498-320220516d2021----kmuy0itay5050 baitaITa 001yyMantova splendore dei GonzagaLorenzo BonoldiMilanoSkira202178 p.ill.28 cmMantovaGuide artisticheGonzaga (famiglia)709.4528Bonoldi,Lorenzo558594ITUNINAREICATUNIMARCBK9910565901103321ART.FI C 350167/2022FARBCFARBCMantova splendore dei Gonzaga2839361UNINA01069nam 22003853 450 991013299010332120031106000000.088-420-7110-2(CKB)3400000000017285(ItFiC)it 02414520(EXLCZ)99340000000001728520101102d2003 uy 0itaPolitica della vita sovranità, biopotere, diritti /a cura di Laura Bazzicalupo, Roberto EspositoRoma [etc.] GLF editori Laterza2003254 p. ;21 cmPercorsi ;57Collected essays.Includes bibliographical references.Politica della vita 320323303190340170327Bazzicalupo Laura1946-231817Esposito Roberto1950-324907ItFiCItFiCBOOK9910132990103321Politica della vita2876805UNINA04273nam 22006735 450 991025387370332120200701082349.03-319-23476-510.1007/978-3-319-23476-2(CKB)3710000000539328(EBL)4199775(SSID)ssj0001596841(PQKBManifestationID)16297241(PQKBTitleCode)TC0001596841(PQKBWorkID)14886361(PQKB)11321395(DE-He213)978-3-319-23476-2(MiAaPQ)EBC4199775(PPN)19088102X(EXLCZ)99371000000053932820151216d2016 u| 0engur|n|---|||||txtccrABC Transporters - 40 Years on /edited by Anthony M. George1st ed. 2016.Cham :Springer International Publishing :Imprint: Springer,2016.1 online resource (384 p.)Description based upon print version of record.3-319-23475-7 Includes bibliographical references.ABC Importers -- Inborn errors and potential correction of the cellular expression and localization of medically important ABC transporters -- Human ABC transporter ABCC11: Molecular mechanistic, pharmacological, and anthropological aspects -- Biology of mitochondrial ABCs and their contribution to pathology -- ABC transporters and multidrug resistance in fungi and yeast -- Structural and mechanistic insights into modulation of P-glycoprotein (ABCB1)function by tyrosine kinase inhibitors -- Techniques for the purification of ABC transporters -- HDAC inhibitors and MDR ABC transporters -- The role of polymorphisms in P-glycoprotein (ABCB1) on function -- Interaction of ABC transporters with drugs -- ABC insights from CFTR.This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders.Cell membranesBiophysicsBiophysicsBiochemistryDrug resistanceMembrane Biologyhttps://scigraph.springernature.com/ontologies/product-market-codes/L16050Biological and Medical Physics, Biophysicshttps://scigraph.springernature.com/ontologies/product-market-codes/P27008Biochemistry, generalhttps://scigraph.springernature.com/ontologies/product-market-codes/L14005Drug Resistancehttps://scigraph.springernature.com/ontologies/product-market-codes/B16020Cell membranes.Biophysics.Biophysics.Biochemistry.Drug resistance.Membrane Biology.Biological and Medical Physics, Biophysics.Biochemistry, general.Drug Resistance.570George Anthony Medthttp://id.loc.gov/vocabulary/relators/edtBOOK9910253873703321ABC Transporters - 40 Years on2532371UNINA