03287nam 2200781 450 991013226170332120220504000034.03-527-67364-43-527-67366-0(CKB)3710000000370188(EBL)1977788(SSID)ssj0001534291(PQKBManifestationID)12590105(PQKBTitleCode)TC0001534291(PQKBWorkID)11494953(PQKB)11705458(MiAaPQ)EBC1977788(Au-PeEL)EBL1977788(CaPaEBR)ebr11048186(CaONFJC)MIL769783(OCoLC)904518353(PPN)19641122X(EXLCZ)99371000000037018820150505h20152015 uy| 0engur|n|---|||||txtccrAntitargets and drug safety /edited by Lásló Urbán, Vinod F. Patel, and Roy J. VazWeinheim, Germany :Wiley-VCH,[2015]©20151 online resource (1266 p.)Methods and principles in medicinal chemistry ;volume 66Description based upon print version of record.3-527-67367-9 3-527-33511-0 Includes bibliographical references and index.section 1. General concept for target-based safety assessment -- section 2. Hepatic side effects -- section 3. Cardiovascular side effects -- section 4. Kinase antitargets -- section 5. Examples of clinical translation.With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusingMethods and principles in medicinal chemistry ;v. 66.DrugsSide effectsDrugsSide effectsPreventionDrug interactionsDrug developmentDrugsStructure-activity relationshipsDrug-Related Side Effects and Adverse ReactionsProtein Kinase Inhibitorsadverse effectsPharmacovigilanceDrugsSide effects.DrugsSide effectsPrevention.Drug interactions.Drug development.DrugsStructure-activity relationships.Drug-Related Side Effects and Adverse Reactions.Protein Kinase Inhibitorsadverse effects,Pharmacovigilance.615.19Urbán LáslóPatel Vinod F.Vaz Roy J.MiAaPQMiAaPQMiAaPQBOOK9910132261703321Antitargets and drug safety2286568UNINA