03924nam 2200733 450 991046351940332120200903223051.090-04-27445-610.1163/9789004274457(CKB)2670000000571179(EBL)1815789(SSID)ssj0001347156(PQKBManifestationID)11888000(PQKBTitleCode)TC0001347156(PQKBWorkID)11344273(PQKB)11154342(MiAaPQ)EBC1815789(OCoLC)895116557(OCoLC)893333672(nllekb)BRILL9789004274457(PPN)184932084(Au-PeEL)EBL1815789(CaPaEBR)ebr10953614(CaONFJC)MIL651267(OCoLC)893333672(EXLCZ)99267000000057117920141021h20152015 uy 0engurun| uuuuatxtccrCategorization and constructional change in Spanish expressions of 'becoming' /Damián Vergara WilsonLeiden, Netherlands :Brill,2015.©20151 online resource (255 p.)Brill's Studies in Historical Linguistics,2211-4904 ;Volume 4Includes index.Revised from author's dissertation "Formulaic language and adjective categories in eight centuries of the Spanish expression of 'becoming' /quedar(se)/ + ADJ", University of New Mexico, 2009.90-04-27444-8 1-322-19987-6 Includes bibliographical references and index.Preliminary Material -- 1 Introduction -- 2 ‘Becoming’ in Spanish -- 3 Data and Methods -- 4 Overview of quedar(se) + adj through Time -- 5 The solo ‘Alone’ Clusters: Continual Expansion with a Robust Central Member -- 6 The rico / pobre ‘Rich / Poor’ Clusters: The Relationship of Opposites in Category Development -- 7 The alegre / satisfecho ‘Happy / Satisfied’ Clusters: Family Resemblance and Changing Central Members -- 8 Similarity Experiment -- 9 Conclusion -- Appendix 1: Adjective Clusters and Tables not Analyzed -- Appendix 2: Sources in the qad -- Works Cited -- Index.In Categorization and Constructional Change Damián Vergara Wilson uses the Spanish change-of-state construction quedar(se) + ADJ to analyze the impact of categorization on constructional change and productivity in data spanning eight centuries. In usage, the appearance of one adjective in the construction triggers the emergence of related ones through analogical extension propelling the expansion of semantic categories of adjectives. Categories develop in different ways reflecting the characteristics of their members in terms of semantics and conventionalization. Emergence tends to relate to the ability of one construction to attract adjective types away from another. This study gives insight into the cognitive status and complex evolution of a schematic construction in a way that supports an instance-based model of memory.Brill's studies in historical linguistics ;Volume 4.Spanish languageFigures of speechSpanish languageVerbSpanish languageAdverbsHistorical linguisticsConstruction grammarElectronic books.Spanish languageFigures of speech.Spanish languageVerb.Spanish languageAdverbs.Historical linguistics.Construction grammar.465/.6Vergara Wilson Damián Chase881798MiAaPQMiAaPQMiAaPQBOOK9910463519403321Categorization and constructional change in Spanish expressions of 'becoming1969477UNINA04728nam 2200661 450 991013223760332120200520144314.01-118-83630-81-118-83650-21-118-83632-4(CKB)3710000000093187(EBL)1650866(SSID)ssj0001131966(PQKBManifestationID)11627931(PQKBTitleCode)TC0001131966(PQKBWorkID)11148656(PQKB)10800144(OCoLC)861789137(MiAaPQ)EBC1650866(DLC) 2013043100(Au-PeEL)EBL1650866(CaPaEBR)ebr10849251(CaONFJC)MIL584561(PPN)224777955(EXLCZ)99371000000009318720140326h20142014 uy 0engur|n|---|||||txtccrCyclic-nucleotide phosphodiesterases in the central nervous system from biology to drug discovery /edited by Nicholas J. Brandon, Anthony R. WestHoboken, New Jersey :Wiley,2014.©20141 online resource (402 p.)Wiley Series in Drug Discovery and DevelopmentDescription based upon print version of record.0-470-56668-X Includes bibliographical references at the end of each chapters and index.Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P. P. Bollen, Kris Rutten, Olga A. H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studiWiley series in drug discovery and development.Cyclic nucleotide phosphodiesterasesCentral nervous systemPhysiologyNucleotides, CyclicCyclic nucleotide phosphodiesterases.Central nervous systemPhysiology.Nucleotides, Cyclic.612.01513Brandon Nicholas J.West Anthony R.1970-MiAaPQMiAaPQMiAaPQBOOK9910132237603321Cyclic-nucleotide phosphodiesterases in the central nervous system2173888UNINA