01251nam1 22003013i 450 SUN011323220180104101728.8640.0020180104d2017 |0itac50 baitaIT|||| |||||*Codice dei contratti pubbliciannotato con dottrina, giurisprudenza, linee guida e delibere Anac e formule[aggiornato al D.Lgs19 aprile 2017n56 c.d. Correttivo del Codice degli Appalti]Roberto Garofoli, Giulia Ferrari7. edRomaNeldiritto20172 volumi25 cm.001SUN01132332001 I *codici del professionista210 RomaNeldiritto.001SUN01132342001 Tomo 1: *D.Lgs18 aprile 2016n50 (Artt1-93)001SUN01132352001 Tomo 2: *D.Lgs18 aprile 2016n50 (Artt94-Allegati)Contratti pubbliciLegislazioneItaliaSGSUNC033541RomaSUNL000360Garofoli, RobertoSUNV005010141353Ferrari, GiuliaSUNV028841231099NeldirittoSUNV009257650ITSOL20181109RICASUN0113232Codice dei contratti pubblici1520295UNICAMPANIA05612nam 2200745 450 991013221910332120200520144314.01-118-89089-21-118-89083-31-118-89090-6(CKB)3710000000113265(EBL)1690924(SSID)ssj0001193900(PQKBManifestationID)11681730(PQKBTitleCode)TC0001193900(PQKBWorkID)11165402(PQKB)11641575(OCoLC)865452420(MiAaPQ)EBC1690924(DLC) 2013049612(Au-PeEL)EBL1690924(CaPaEBR)ebr10870606(CaONFJC)MIL611514(PPN)22157252X(EXLCZ)99371000000011326520140522h20142014 uy 0engurcnu||||||||txtccrDried blood spots applications and techniques /edited by Wenkui Li, Mike S. LeeHoboken, New Jersey :Wiley,2014.©20141 online resource (377 p.)Wiley Series on Pharmaceutical Science and Biotechnology : Practices, Applications and MethodsIncludes index.1-118-05469-5 Includes bibliographical references at the end of each chapters and index.Dried Blood Spots; Contents; Preface; Contributors; PART I History, Applications, and Healthcare; 1 Overview of the History and Applications of Dried Blood Samples; 1.1 History; 1.2 Historical Applications; 1.3 Overall Advantages and Disadvantages of Dried-Blood Spot Sampling; 1.3.1 Advantages; 1.3.2 Disadvantages; 1.4 Conclusion; References; 2 Dried Blood Spot Cards; 2.1 Introduction; 2.2 Filter Paper; 2.3 Filter Paper Sources; 2.4 Guidelines and Printing; 2.5 Printing Adaptations; 2.6 Further Innovations in Manufacturing; 2.7 Filter Paper Cards Construction2.8 Wraparound Cover and Cassette Construction 2.9 Filter Paper Pre-Treatment; 2.10 The Future of the Filter Paper Card; References; 3 Dried Blood Spot Sample Collection, Storage, and Transportation; 3.1 Introduction; 3.2 General Procedures and Precautions for DBS Sample Collection; 3.2.1 Reagents and Materials; 3.2.2 Biosafety and Infection Control; 3.2.3 Specimen Collection; 3.2.4 DBS Prepared by Other Collection Methods; 3.2.5 Labeling of DBS; 3.2.6 Drying; 3.3 Sample Storage and Transportation; 3.3.1 Packaging and Storage; 3.3.2 Transportation3.4 Common Errors in Sample Collection, Storage, and Shipment 3.5 Conclusions; Disclaimer; References; 4 Dried Blood Spot Specimens for Polymerase Chain Reaction in Molecular Diagnostics and Public Health Surveillance; 4.1 Introduction; 4.2 Pioneering DBS Nucleic Acid Extraction Methods for PCR; 4.3 Direct PCR Amplification of Targeted Genomic DNA from DBS; 4.4 Expansion of DBS-PCR from Newborn Screening to Diagnosis of Infectious and other Diseases; 4.5 Application of DBS-PCR in Sequencing-Based Molecular Epidemiology Analyses4.6 Application of DBS-PCR for HIV Drug Resistance Surveillance and Monitoring in Resource-Limited Settings4.7 Quantitation of Infectious Agent Particles with DBS-PCR; 4.8 Conclusions; References; 5 Application of Enzyme Immunoassay Methods Using Dried Blood Spot Specimens; 5.1 Introduction; 5.2 Overview of Basic ELISA Systems; 5.2.1 Antibody Detection; 5.2.2 Variation of ELISA Method for Antibody Detection; 5.2.3 Variations of ELISA for Antigen Detection; 5.3 Applications of ELISA Methods Using DBS; 5.4 Optimization and ELISA Methods Validation Using DBS Specimens; 5.4.1 DBS Elution Protocol5.4.2 Defining Cutoff Values5.5 Factors Influencing the Performance of DBS-based ELISA Methods; 5.5.1 DBS Preparation; 5.5.2 Anticoagulant; 5.5.3 Punching; 5.5.4 Cross-Contamination; 5.6 Conclusions; Disclaimer; References; 6 Applications of Dried Blood Spots in Newborn and Metabolic Screening; 6.1 Introduction; 6.1.1 History and Chronology in the Use of DBS in NBS; 6.1.2 Chapter Organization and Perspectives; 6.2 Fundamentals of Dried Blood Spots; 6.2.1 A Class II Medical Device; 6.2.2 Liquid versus Dried Blood Specimens; 6.2.3 Interaction of Paper with Biological Matrix and Substrates6.2.4 Sample Collection and DBSThis book covers the fundamentals, experimental procedures, and applications of dried blood spot (DBS) sampling in combination with various qualitative and quantitative analytical techniques. This includes sample collection, storage, transportation, and sample preparation for various analysis. Experimental examples in newborn screening, toxicokinetics and pharmacokinetics, and forensics are also given. Finally, the book provides an overview of trends in quantitative and qualitative analysis of DBS samples as well as future perspectives. This provides a valuable working guide to researchers,Wiley series on pharmaceutical science and biotechnology.BloodCollection and preservationPhlebotomyForensic hematologyForensic serologyBloodCollection and preservation.Phlebotomy.Forensic hematology.Forensic serology.616.07/561Li Wenkui1964-Lee Mike S.1960-MiAaPQMiAaPQMiAaPQBOOK9910132219103321Dried blood spots1915094UNINA10311nam 22006015 450 991073601550332120251116182942.010.1007/978-3-319-31512-6(CKB)3710000001632592(DE-He213)978-3-319-31512-6(PPN)24284149X(EXLCZ)99371000000163259220190617d2020 u| 0engurnn#008mamaatxtrdacontentcrdamediacrrdacarrierTextbook of Pediatric Neurosurgery /edited by Concezio Di Rocco, Dachling Pang, James T. RutkaCham :Springer International Publishing :Imprint: Springer,2020.3-319-31512-9 1.Generalities: Embryology of CNS.-Neurologic development and objective neurological examination of the infant and the child -- Principles of neuroimaging.-Neurologic development and objective neurological examination of  the infant and the child -- Physiological responses of the newborn, infant and child to neurosurgical trauma.-Preoperative evaluation, anesthesiological and intensive care management.-Pediatric chemotherapy.-Pediatric radiotherapy.-2. Congenital brain malformation and acquired disorders: Encephaloceles, meningoceles, dermal sinuses -- Chiari malformations (types II,III,IV) .-Craniopagus -- Physiology and abnormalities of CSF dynamics (including infantile benign hydrocephalus and benign intracranial hypertension) .-Hydrocephalus: Clinical presentation according to age and etiology.-Pathological changes induced by the hydrocephalus/ compensative changes.-Hydrocephalus: Neuroimaging.-Fetal hydrocephalus and its treatment in utero.-Posthemorrhagic hydrocephalus.-Postinfective hydrocephalus.-Multiloculated hydrocephalus.-Aqueductal stenosis and hydrcephalus.-X-linked, metabolic hydrocephalus.-Hydrocephalus associated to MM.-Hydrocephalus associated to tumors.-Medical treatment of hydrocephalus.-Surgical treatment of hydrocephalus based on CSF shunt devices.-In-depth view: Functional chracteristics of CSF shunt devices (pros and cons) .-In-depth view: How to perform a V-P CSF shunt.-In-depth view: How to perform a V-A CSF shunt.-In-depth view: How to perform a lumbo-peritoneal CSF shunt.-In-depth view: How to perform a pleural, glad bladder shunt.-In-depth view: How to perform a subgaleal shunt.-In-depth view: External CSF shunts.-Infective, mechanical and functional complications in the surgical treatment of hydrocephalus.-Late complications following surgical treatment of hydrocephalus.-Endoscopic treatment of hydrocephalus.-In-depth view: How to perform an endoscopic third-ventricle cisternostomy.-In-depth view: How to perform an endoscopic plexectomy.-Complications following endoscopic treatment of hydrocephalus.-Arachnoid cysts.-Dandy-Walker malformations/variants.-Cortical dysplasia.-Neurocutaneous syndromes.-Neurofibromatosis.-SturgeWeber.-Tuberous sclerosis.-HippelLindau.-Hemimegalencephaly.-Cerebrocutaneous melanosis -- .Encephalo cutaneous lipomatosis.-3. Cerebrovascular diseases: Vein of Galen aneurysmal malformations.-Artero-venous malformations.-Venous angiomas and cavernomas.-Cerebral aneurysms.-Moya-moya disease.-4. Congenital malformations of the skull and its coverings: Craniosynostoses: Management Issues and Evolution in concepts.-Craniosynostoses: Genetic base, genes, chromosomes and resulting syndromes.-Craniosynostoses: Lessons learned from animal models.-Sagittal synostoses.-Coronal (uni and bilateral) synostoses.-Metopic synostoses.-Lambdoid synostoses.-Non syndromic plurisutural synostoses (oxycephaly, Mercedes) .-Syndromic synostoses.-Secondary synostoses (Metabolic, Iatrogenic, osteopetrosis, etc) .-In-depth view: ICP in craniosynostosis.-In-depth view: Neuropsychological evaluation in craniosynostosis.-In-depth view: Psycho-Sociological repercussions of craniosynostosis.-In-depth view: Deformational plagiocephaly.-In-depth view: Management of craniosynostosis: Evaluation of results.-In-depth view: Blood sparing and anesthesiological issues in craniosynostosis.-In-depth view: Osteogenic distraction.-In-depth view: Endoscopy assisted techniques.-In-depth view: Spring assisted distraction.-In-depth view: Bone splitting and materials.-Scalp agenesis. .- 5. Head Injuries: Birth related head traumas.-Accidental head traumas.-Non-accidental head injuries.-Cranial decompression.-Outcomes, principles of rehabilitation.-6. Infections: Meningitis: neurosurgical implications -- .Encephalitis.-Empyemas and brain abscesses.-Parasitic infestations, fungal and TB.- 7. Neoplasms: Genetic basis and classification of cerebral neoplasms.-Familial syndromes.-Congenital and infantile tumors.-Cerebral gliomas.-Thalamic gliomas.-Optic pathways gliomas.-Pituitary adenomas.-Craniopharyngiomas and Rathke cysts.-Pineal region tumors.-Brainstem tumors.-Cerebellar astrocytomas.-Medulloblastomas -- Ependymomas.-Meningiomas -- Skull base tumors.-Skull tumors -- .-8. Functional disorders: Epilepsy: genetic forms and sporadic forms.-Medical intractable epilepsy: preoperative evaluation.-Catastrophic epilepsy and hemispherectomy.-Temporal lobe epilepsy surgery.-Extra-temporal epilepsy surgery.-Palliative surgical techniques (VNS, Callosotomy) .-Neuromodulation.-Spasticity.-Movement disorders.-9. Congenital and developmental spinal disorders: Genetic basis of neural tube defects.-Classification of spinal dysraphic malformations according to embryogenesis: Gastrulation defects and Split cord malformation.-Primary neurulation defects: 1 Open neural tube defects.-Primary neurulation defects : 2 Limited dorsal myeloschisi (LDM) .Dermoid and dermal sinus tracts.-Secondary neurulation defects -1: Thickened filum terminale; Retained medullary cord.-Secondary neurulation defects -2: Terminal myelocystocoele.-Mixed primary and secondary neurulation defects: spinal cord lipomas.-Antenatal management of spinal dysraphysm-1: Imaging and diagnosis of antenatal spinal and spinal cord malformations.-Antenatal management of spinal dysraphysm-2: Antenatal surgery of myelominingocoele.-Caudal agenesis and associated spinal cord malformations.-Spinal cord and vertebral arteriovenous malformation and fistula.-Intraspinal cysts including syringomyelia unrelated to Chiari Malformation.-Scoliosis and other congenital vertebral anomalies. 10. Craniovertebral Junction Anomalies: Embryology, classification, and surgical management of bony malformations of the craniovertebral junction.-Chiari I Malformation and associated syringomyelia.-Anterior surgical approaches to the craniovertebral junction and upper cervical spine. 11. Spine and spinal cord neoplasms: Intramedullary tumours -- Extramedullary tumours.-Vertebral tumours. 12. Spinal trauma: Spine and spinal cord injuries in children: General aspects including Pure ligamentous injuries in children.-Spinal cord injury without radiographic abnormality (SCIWORA) .-Atlantooccipital dislocation (AOD) in children.-Atlantoaxial rotatory fixation (AARF) in children.-Outcome and principles of spinal cord rehabilitation in children. 13. Infectious diseases of the spine: Tuberculosis of the spine.-Bacterial, fungal, and other non-tuberculous infections of the spine, including intraspinal abscesses.-Juvenile disc diseases of the spine including infectious and non-infectious acute discitis.-14. Intraoperative Neurophysiology Monitoring: Intraoperative neurophysiology monitoring for surgery of the brain.-Intraoperative neurophysiology monitoring for surgery of the spine and spinal cord.This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supported by a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.Nervous systemSurgeryPediatricsNeurologyCancerSurgeryMouthSurgeryMaxillaSurgeryNeurosurgeryhttps://scigraph.springernature.com/ontologies/product-market-codes/H39000Pediatricshttps://scigraph.springernature.com/ontologies/product-market-codes/H49006Neurologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H36001Surgical Oncologyhttps://scigraph.springernature.com/ontologies/product-market-codes/H59150Oral and Maxillofacial Surgeryhttps://scigraph.springernature.com/ontologies/product-market-codes/H59060Nervous systemSurgery.Pediatrics.Neurology.CancerSurgery.MouthSurgery.MaxillaSurgery.Neurosurgery.Pediatrics.Neurology.Surgical Oncology.Oral and Maxillofacial Surgery.617.48Di Rocco C(Concezio),edthttp://id.loc.gov/vocabulary/relators/edtPang Dachlingedthttp://id.loc.gov/vocabulary/relators/edtRutka James T.edthttp://id.loc.gov/vocabulary/relators/edtBOOK9910736015503321Textbook of Pediatric Neurosurgery1736777UNINA