05502nam 2200721 450 991013221610332120230519080349.01-118-46877-51-118-46879-11-118-46876-7(CKB)3710000000096945(EBL)1658805(SSID)ssj0001132517(PQKBManifestationID)11610992(PQKBTitleCode)TC0001132517(PQKBWorkID)11167139(PQKB)10639831(OCoLC)878147451(MiAaPQ)EBC1658805(DLC) 2014006445(Au-PeEL)EBL1658805(CaPaEBR)ebr10855754(CaONFJC)MIL586306(OCoLC)871186971(EXLCZ)99371000000009694520140412h20142014 uy 0engur|n|---|||||txtccrLung cancer /edited by Jack A. Roth [and five others]Fourth edition.Hoboken, New Jersey :Wiley-Blackwell,2014.©20141 online resource (634 p.)Description based upon print version of record.1-118-46874-0 Includes bibliographical references at the end of each chapters and index.Lung Cancer; Contents; Contributors; Preface; CHAPTER 1 Smoking Prevention and Cessation; Overview; Introduction; Tobacco and lung cancer; Secondhand smoke andlung cancer; Smoking among lungcancer patients; Forms of tobacco; Smoked tobacco; Smokeless tobacco; Recent developments on the tobacco market; Factors explaining tobacco use; Smoking initiation; Smoking prevention; Nicotine addiction; Benefits of quitting; Smoking cessation interventions; Behavioral counseling; Pharmaceutical aids for smoking cessation; Nicotine replacement therapy; Sustained-release bupropion; VareniclineCombination therapyUse of medications in pregnancy; Summary; References; CHAPTER 2 Lung Cancer Susceptibility and Risk Assessment Models; Introduction; Epidemiologic risk factors; Family history; Prior inflammatory diseases and disorders; Diet and nutritional risk factors; Genetic susceptibility; Candidate gene approaches; Genome-wide association studies; 6p21 and 12p13; Intermediate phenotypic assays in measuring genetic susceptibility; DNA damage and repair phenotypic assays; Cell cycle phenotypic assays; Phenotypic assays in apoptotic pathwaysEmerging novel biomarkers for LC risk and early detectionLC risk assessment models; An overview of cancer risk prediction models; Concluding remarks; References; CHAPTER 3 Molecular Profiling; Introduction; Techniques used in molecular profiling; DNA sequencing; RNA profiling; Proteomics; Data analysis and statistics; Clinical applications; Early detection and diagnosis; Molecular subclassification and staging; Selection of therapy; Future directions and conclusions; Acknowledgments; References; CHAPTER 4 Somatic Genome Alterations in Human Lung Cancers; Lung cancer genetics overviewLung adenocarcinoma genomicsMolecular alteration spectra of lung adenocarcinoma; Key genetic alterations in lung adenocarcinoma in a few selected pathways; Genetic correlates of sensitivity and resistance; Germline predisposition; Future directions; Lung squamous cell carcinoma genomics; Introduction and overview of genomic alterations of lung SqCCs; Somatic copy number alterations; Genomic features of small cell lung cancers; Previous molecular findings in SCLC; Large-scale genome analysis studies of SCLC; Biological and clinical implications of SCLC genome alterations; ReferencesCHAPTER 5 Serum Proteomic BiomarkersNatural history of lung cancer progression and potential utility for biomarkers in the clinic; The blood proteome; Proteomic discovery platforms; Proteomic approaches for discovery and validation of blood biomarkers; MALDI-TOF MS serum analysis for diagnosis; Serum proteomics for response to therapy; Strategies to address serum proteome complexity; Liquid chromatography (LC) tandem mass spectrometry (MS/MS); Targeted proteomics using multiple reaction monitoring (LC MRM MS); Bio-analytical validation of serum protein biomarkers; Circulating autoantibodiesClinical validation of serum biomarkersLung Cancer is a comprehensively revised and expanded edition the well-established, concise, multidisciplinary reference book dealing with advances in lung cancer clinical research and treatment for the clinician. Edited and authored by leading authorities in the field, it is the best concise single source for state-of-the-art diagnosis and treatment of lung cancer. The new fourth edition is now better than ever, incorporating the most recent work in the field of lung cancer research, diagnosis, and treatment. This book has always been well known and highly regarded for its concise presLungsDiseasesDiagnosisLungsCancerTreatmentLungsCancerCancerDiagnosisLungsDiseasesDiagnosis.LungsCancerTreatment.LungsCancer.CancerDiagnosis.616.99/424Roth Jack A.MiAaPQMiAaPQMiAaPQBOOK9910132216103321Lung cancer1890569UNINA