03608nam 2200769 450 991013153230332120230621140022.0(CKB)3710000000504554(SSID)ssj0001684438(PQKBManifestationID)16517288(PQKBTitleCode)TC0001684438(PQKBWorkID)15045020(PQKB)10027718(WaSeSS)IndRDA00056947(oapen)https://directory.doabooks.org/handle/20.500.12854/55434(EXLCZ)99371000000050455420160829d2014 fy 0engur||#||||||||txtrdacontentcrdamediacrrdacarrierThe origin, function and diagnostic potential of extracellular microRNA in human body fluids /topic editors: Andrey Turchinovich and William ChoFrontiers Media SA2014[Lausanne, Switzerland] :Frontiers Media SA,[2014]©20141 online resource (114 pages) illustrations; digital file(s)Frontiers Research Topics,1664-8714Bibliographic Level Mode of Issuance: Monograph"Published in: Frontiers in genetics" -- front cover.Print version: 2889192423 Includes bibliographical references.Short non-coding RNA molecules, microRNAs (miRNAs), post-transcriptionally regulate gene expression in living cells. In recent years, miRNAs have been found in a wide spectrum of mammalian body fluids including blood plasma, saliva, urine, milk, seminal plasma, tears and amniotic fluid as extracellular circulating nuclease-resistant entities. The changes in miRNA spectra observed in certain fluids correlated with various pathological conditions suggesting that extracellular miRNAs can serve as informative biomarkers for certain diseases including cancer. However, the mechanism of generation and a biological role of extracellular miRNAs remain unclear. The current theories regarding extracellular miRNA origin and function suggest that these miRNAs can be either non-specific 'by-products' of cellular activity and cell death or specifically released cell-cell signaling messengers. The goal of this Research Topic is to bring together up-to-date knowledge about the extracellular miRNA and its role in disease diagnostics and, possibly, inter-cellular communication.Frontiers research topics.MicroRNABlood plasmaBloodDiseasesGeneticsEpigeneticsHematologic DiseasesHILCCMedicineHILCCHealth & Biological SciencesHILCCextracellular miRNAexosomal miRNAblood plasmablood serumcirculating miRNAArgonaute Proteinscell-cell communicationbiological fluidsMicroRNA.Blood plasma.BloodDiseases.Genetics.Epigenetics.Hematologic DiseasesMedicineHealth & Biological SciencesWilliam Choauth1364863Turchinovich AndreyCho William C. S.PQKBUkMaJRUBOOK9910131532303321The origin, function and diagnostic potential of extracellular microRNA in human body fluids3386306UNINA