03074nam 2200601 450 991013153180332120230808212415.01-118-91434-11-118-81958-61-118-81944-6(CKB)3710000000498432(EBL)4435614(MiAaPQ)EBC4435614(DLC) 2015030480(Au-PeEL)EBL4435614(CaPaEBR)ebr11169625(CaONFJC)MIL902575(OCoLC)915775232(EXLCZ)99371000000049843220160331h20162016 uy 0engur|n|---|||||rdacontentrdamediardacarrierAttrition in the pharmaceutical industry reasons, implications, and pathways forward /edited by Alexander Alex, C. John Harris, Dennis A. SmithHoboken, New Jersey :Wiley,2016.©20161 online resource (373 p.)Includes index.1-118-67967-9 Includes bibliographical references and index.Attrition in drug discovery and development / Scott Boyer, Clive Brealey and Andrew M. Davis -- Compound attrition at the pre-clinical phase / Cornelis E.C.A. Hop -- Attrition in phase I / Dennis A. Smith and Thomas A. Baillie -- Compound attrition in phase II/III / Alexander Alex, C. John Harris, Wilma W. Keighley and Dennis A. Smith -- Post-marketing attrition / Dennis A. Smith -- Influence of the regulatory environment on attrition / Robert T. Clay -- Experimental screening strategies to reduce attrition risk / Marie-Claire Peakman, Matthew Troutman, Rose Gonzales and Anne Schmidt -- Medicinal chemistry strategies to prevent compound attrition / J. Richard Morphy -- Influence of phenotypic and target-based screening strategies on compound attrition and project choice / Andrew Bell, Wolfgang Fecke and Christine Williams -- In silico approaches to address compound attrition / Peter Gedeck, Christian Kramer, Richard Lewis -- Current and future strategies for improving drug discovery efficiency / Peter Mbugua Njogu and Kelly Chibale -- Impact of investment strategies, organizational structure and corporate environment on attrition, and future investment strategies to reduce attrition / Geoff Lawton.Pharmaceutical industryManagementPharmaceutical industryCapital productivityIndustrial efficiencyDrug developmentPharmaceutical industryManagement.Pharmaceutical industryCapital productivity.Industrial efficiency.Drug development.615.1068/5Alex Alexander A.1242845Alex AlexanderHarris C. JohnSmith Dennis A.MiAaPQMiAaPQMiAaPQBOOK9910131531803321Attrition in the pharmaceutical industry2882999UNINA