02567nam 2200433z- 450 991013152930332120230221130312.0(CKB)3710000000504571(oapen)https://directory.doabooks.org/handle/20.500.12854/40172(EXLCZ)99371000000050457120202102d2015 |y eengurmn|---annantxtrdacontentcrdamediacrrdacarrierAdult neurogenesis twenty years later: physiological function versus brain repairFrontiers Media SA20151 electronic resource (120 p.)Frontiers Research Topics2-88919-494-9 The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity. On a theoretical basis, this achievement opened new perspectives for therapeutic approaches in restorative and regenerative neurology. Nevertheless, in spite of striking advancement concerning the molecular and cellular mechanisms which allow and regulate the neurogenic process, its exploitation in mammals for brain repair strategies remains unsolved. In non-mammalian vertebrates, adult neurogenesis also contributes to brain repair/regeneration. In mammals, neural stem cells do respond to pathological conditions in the so called "reactive neurogenesis", yet without substantial regenerative outcome. Why, even in the presence of stem cells in the brain, we lack an effective reparative outcome in terms of regenerative neurology, and which factors hamper the attainment of this goal? Essentially, what remains unanswered is the question whether (and how) physiological functions of adult neurogenesis in mammals can be exploited for brain repair purposes.Adult neurogenesis twenty years laterNeurodegenerative Diseasesstructural plasticitybrain repairCell specificationcell therapycell migrationbrain evolutionNeural Stem CellsRegenerative Medicinetherapeutic approachesPaolo Perettoauth1287760Luca BonfantiauthBOOK9910131529303321Adult neurogenesis twenty years later: physiological function versus brain repair3020360UNINA