03088nam 2200577zu 450 991013136730332120230621140026.09782889195756 (ebook)(CKB)3710000000494913(SSID)ssj0001680122(PQKBManifestationID)16496183(PQKBTitleCode)TC0001680122(PQKBWorkID)15028370(PQKB)11407573(WaSeSS)IndRDA00057291(oapen)https://directory.doabooks.org/handle/20.500.12854/45324(EXLCZ)99371000000049491320160829d2015 uy |engur|||||||||||txtccrDNA helicases[electronic resource] expression, functions and clinical implications /topic editors Fumiaki Uchiumi, Masayuki Seki and Yasuhiro FuruichiFrontiers Media SA2015France :Frontiers Media SA,20151 online resource (78 pages) illustrations, colour chartsFrontiers Research TopicsBibliographic Level Mode of Issuance: MonographIncludes bibliographical references.Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases.Animal BiochemistryHILCCHuman Anatomy & PhysiologyHILCCHealth & Biological SciencesHILCCDNA RepairAginghelicasesTelomereCancerAnimal BiochemistryHuman Anatomy & PhysiologyHealth & Biological SciencesFumiaki Uchiumiauth1365041Furuichi YasuhiroUchiumi FumiakiSeki MasayukiPQKBUkMaJRU9910131367303321DNA helicases3386697UNINA