05230nam 2200601 450 991013115220332120230807213958.01-118-82853-41-118-82855-0(CKB)3710000000373646(EBL)1895634(Au-PeEL)EBL1895634(CaPaEBR)ebr11033001(CaONFJC)MIL769858(OCoLC)890080333(MiAaPQ)EBC1895634(EXLCZ)99371000000037364620150326h20152015 uy 0engurcnu||||||||rdacontentrdamediardacarrierAtherosclerosis risks, mechanisms and therapies /edited by Hong Wang and Cam Patterson ; co-editors, Domenico Praticò [and others]Hoboken, New Jersey :John Wiley & Sons,2015.©20151 online resource (631 p.)Description based upon print version of record.1-118-28591-3 Includes bibliographical references and index.Title Page; Copyright Page; Contents; Contributors; Foreword; Preface; Section I Risk Factors: Old and New; Chapter 1 Lipoproteins; Brief History of Cholesterol and Atherosclerosis; Lipoproteins; LDL and Atherosclerosis; Triglyceride-Rich Lipoproteins and Atherosclerosis; HDL and Atherosclerosis; Summary; References; Chapter 2 Role of Dysglycemia in Atherosclerosis; Introduction; Molecular Mechanisms by Which Dysglycemia Accelerates Atherosclerosis; Dysglycemia and Endothelial Cells; Dysglycemia and Vascular Smooth Muscle Cells; Dysglycemia and Macrophages; Conclusion; AcknowledgmentsReferences Chapter 3 Glycation, Inflammation and RAGE: Mechanisms Contributing to the Accelerated Atherosclerosis of Diabetes; Introduction; Animal Models of Diabetic Atherosclerosis; Glycation of Proteins and Lipids: Potential Impact on Atherosclerosis; Non-RAGE Glycation Receptors and Implications for Atherosclerosis; RAGE and Implications for Diabetic Atherosclerosis; Glycation and Rage-Studies in Human Subjects; Conclusions; References; Chapter 4 Inflammation; Introduction; Monocyte Recruitment to the Vessel Wall; Chemokines; Cytokines; Shear Stress and InflammationMechanisms of Flow-Induced Inflammation Conclusions; References; Chapter 5 Homocysteine: A Controversial Cardiovascular Risk Factor; Introduction; Epidemiological Studies: Establishment of Homocysteine as a Risk Factor; Animal Models of Hyperhomocysteinemia; Clinical Intervention Trials; Summary and Perspectives; References; Chapter 6 Hypertension as a Risk Factor for Atherosclerosis; Introduction; Evidence Linking Atherosclerosis and Hypertension; Molecular and Cellular Mechanisms Linking Hypertension and Atherosclerosis; Implications for Treatment and Future Directions; ReferencesChapter 7 The Genetics of Atherosclerosis: From Polymorphisms to Populations Introduction; Lessons from Mendelian Diseases-Familial Hypercholesterolemia; Role for Genetic Diagnosis and Screening; Genetically Isolated Population Studies: Implications for Atherosclerosis in the General Population; GWAS to Identify Atherosclerosis Risk Genes in the General Population; Identification of a Risk Allele Located at 9P21 by GWAS; Technologic Advances and the Future; Conclusion; Acknowledgments; References; Chapter 8 Life Style; Introduction; Lifestyle Factors and Cardiovascular DiseaseLifestyle Factors and Cardiovascular Disease in the Young Physical Activity; Diet and Nutrition; Environmental Effects; Ambient Air Pollution; Other Environmental Factors; Summary; References; Section II Cellular Mechanisms; Chapter 9 Endothelial Cells; Introduction; Endothelial Nitric Oxide; Flow and Arterial Shear Stress; Peroxisome Proliferator-Activated Receptor Nuclear Receptor Family; Endothelial Progenitor Cells; Future Directions; References; Chapter 10 Vascular Smooth Muscle Cells; Introduction; SMCS in Atheroma Progression; Extrinsic Control of SMC BiologyIntrinsic Control of SMC BiologyComprehensive and in-depth in its coverage, Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and Novel Therapy reviews the recent progress in atherosclerosis research and offers cutting edge perspectives from experts in the field. Written by an international team of authors including leading physician-scientists, research experts and physicians, chapters are divided into four major sections, covering risk factors, cellular and molecular mechanisms, biochemical mechanisms and novel and future therapeutics. Atherosclerosis: Cellular, Molecular & Biochemical Mechanism and NovelAtherosclerosisAtherosclerosisPathophysiologyAtherosclerosisPreventionAtherosclerosis.AtherosclerosisPathophysiology.AtherosclerosisPrevention.616.136Wang HongPatterson CamMiAaPQMiAaPQMiAaPQBOOK9910131152203321Atherosclerosis729078UNINA