00846nam0-2200301---450-99000819521040332120050929105451.00713462620000819521FED01000819521(Aleph)000819521FED0100081952120050929d1990----km-y0itay50------baengGBy---n----00yyRome's desert frontier from the airDavid Kennedy & Derrick RileyLondonBatsford1990256 p.ill26 cmKennedy,David163908Riley,Derrick459583ITUNINARICAUNIMARCBK990008195210403321DDR-XXIII D 0811145 ddrDDR21-8187DDRRome's desert frontier from the air734448UNINA04649nam 2201093z- 450 991055759550332120210501(CKB)5400000000043722(oapen)https://directory.doabooks.org/handle/20.500.12854/68283(oapen)doab68283(EXLCZ)99540000000004372220202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCharacterization and Clinical Management of Dilated CardiomyopathyBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (232 p.)3-03943-761-5 3-03943-762-3 Dilated cardiomyopathy (DCM) is a particular phenotype of non-ischemic systolic heart failure, frequently recognizing a genetic background and affecting relatively young patients with few comorbidities. Nowadays, long-term survival of DCM patients has been markedly improved due to an early diagnosis and uninterrupted and tailored follow-up under constant optimal medical and non-pharmacological evidence-based treatments. Nevertheless, DCM is still one of the most common causes of heart transplantation in the western world. Clinical management requires an integrated and systematic use of diagnostic tools and a deeper investigation of the basic mechanisms underlying the disease. However, several emerging issues remain debated. Specifically, the genotype-phenotype correlation, the role of advanced imaging techniques and genetic testing, the lack of appropriate risk stratification models, the need for a multiparametric and multidisciplinary approach for device implantation, and a continuous reclassification of the disease during follow-up remain challenging issues in clinical practice. Therefore, the aim of this Special Issue is to shed the light on the most recent advancements in characterization and clinical management of DCM in order to unveil the conundrum of this particular disease.Medicinebicsscalternative splicingarrhythmiasarrhythmic risk stratificationatrial fibrillationbiomarkerscalciumcardiac channelopathycardiac magnetic resonancecardiac magnetic resonance imagingcardiac resynchronization therapycardiac sodium channelcardiomyopathycongenital heart diseasecongestive heart failuredesmindiastolic dysfunctiondilated cardiomyopathyDNA methylationduchenne muscular distrophyepigeneticsgene therapygeneticsheartheart failurelaminopathylate gadolinium enhancementleft atrial strainleft ventricle non-compaction cardiomyopathyleft ventricle sphericity indexleft ventricular noncompactionleft ventricular reverse remodellingLMNAlong axis strainlong-term outcomesmajor adverse cardiovascular eventsmalignant ventricular arrhythmiamammalian target of rapamycin (mTOR) complex-1mdxmembrane stabilizationmitochondrial dysfunctionmuscular dystrophymyopathyn/anon-ischemic cardiomyopathynon-sense mRNA decaynonischemic dilated cardiomyopathyNT-proBNPoxidative stressphospholambanphosphorylationprecision medicineRNA binding motif protein 20 (RBM20)sarcomereSCN5ASerca2asex differencessupraventricular arrhythmiasystolic dysfunctiontachycardiomyopathytitintroponin Tventricular arrhythmiawhole exome sequencingMedicineMerlo Marcoedt1292384Merlo MarcoothBOOK9910557595503321Characterization and Clinical Management of Dilated Cardiomyopathy3022238UNINA01560nam0 22003853i 450 AQ1000132920251003044040.0081868976520080116d1991 ||||0itac50 baengusz01i xxxe z01nX.25 and related protocolsUyless BlackLos AlamitosIEEE Computer Society Pressc1991XXI, 288 p.ill.27 cmIEEE Computer Society Press monographs001AQ100013312001 IEEE Computer Society Press monographsX.twentyfive and related protocolsAQ10001330Reti di elaboratoriprotocolliFIRLIGC002598E004.6ELABORAZIONE DEI DATI. INTERFACCIAMENTO E COMUNICAZIONI14004.62Interfacciamento e comunicazioni. Protocolli (Standard)22Reti di calcolatoriReti di computerReti di elaboratoriReti di calcolatoriReti di elaboratoriReti di computerBlack, UylessAQ1V00304507041864Black, Uyless D.CFIV153124Black, UylessITIT-00000020080116IT-BN0095 NAP 01SALA DING $AQ10001329Biblioteca Centralizzata di Ateneo1 v. 01SALA DING 004.6 BLA.x.2 0102 0000008715 VMA A4 1 v. (3. rist. 1993)Y 2008011620080116 01X.25 and related protocols1571118UNISANNIO