01096cam0-22003251i-450-99000706108040332120070706121410.088-8233-166-0000706108FED01000706108(Aleph)000706108FED0100070610820020312d2001----km-y0itay50------baitaITy-------001yyProfessionisti e lavoratori autonomidalla verifica fiscale al contenzioso tributarioFisco 2001indispensabile a Professionisti e Consulenti fiscali, Funzionari delle Finanze, Guardia di Finanza, Enti pubblici, Associazioni di categoria : Artigiani e CommerciantiGiovanni Maugeri11 ed.MilanoFAG©2001416 p.25 cmTributiGuide336.221itaMaugeri,Giovanni413486ITUNINARICAUNIMARCBK990007061080403321VIII C 12837135FSPBCFSPBCProfessionisti e lavoratori autonomi708147UNINA03797nam 2200637Ia 450 991079227380332120230721015253.097866111452551-281-14525-40-19-856922-X0-19-152458-11-4294-6993-5(CKB)2560000000293036(EBL)415065(OCoLC)476239685(SSID)ssj0000100421(PQKBManifestationID)11108488(PQKBTitleCode)TC0000100421(PQKBWorkID)10036574(PQKB)11113867(StDuBDS)EDZ0000075928(MiAaPQ)EBC415065(Au-PeEL)EBL415065(CaPaEBR)ebr10167550(CaONFJC)MIL114525(EXLCZ)99256000000029303620061004d2007 uy 0engur|n|---|||||txtccrAging of the genome[electronic resource] the dual role of DNA in life and death /Jan VijgOxford Oxford University Press20071 online resource (385 p.)Description based upon print version of record.0-19-856923-8 0-19-172824-1 Includes bibliographical references.Contents; Preface; 1 Introduction: the coming of age of the genome; 1.1 The age of biology; 1.2 From genetics to genomics; 1.3 A return to function; 1.4 The causes of aging: a random affair; 2 The logic of aging; 2.1 Aging genes; 2.2 Pleiotropy in aging; 2.3 Interrupting the pathways of aging; 2.4 Longevity-assurance genes; 2.5 Somatic damage and the aging genome; 3 Genome structure and function; 3.1 DNA primary structure; 3.2 Higher-order DNA structure; 3.3 Nuclear architecture; 3.4 Transcription regulation; 3.5 Conclusions; 4 Genome maintenance; 4.1 Why genome maintenance?4.2 DNA-damage signaling and cellular responses4.3 DNA-repair mechanisms; 4.4 Genome maintenance and aging; 5 Genome instability and accerated aging; 5.1 Premature aging; 5.2 Validity of accelerated-aging phenotypes; 5.3 Genome maintenance and accelerated aging in mice; 5.4 Conclusions; 6 The aging genome; 6.1 DNA damage; 6.2 DNA-sequence changes; 6.3 Changes in DNA modification and conformation; 6.4 Summary and conclusions: a DNA damage report of aging; 7 From genome to phenome; 7.1 The causes of cancer; 7.2 Genome instability and tissue dysfunction7.3 Testing the role of genome instability in aging8 A genomic limit to life?; 8.1 Aiming for immortality; 8.2 SENS, and does it make sense?; EPILOGUE; GLOSSARY; A; B; C; D; E; F; G; H; I; L; M; N; O; P; R; S; T; X; Y; Z; REFERENCES; INDEX; A; B; C; D; E; F; G; H; I; J; K; L; M; N; O; P; Q; R; S; T; U; V; W; X; Y; ZAging has long been ascribed to the gradual accumulation of mutations in the genome. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. This book reviews the concept of genomic instability as a possible universal cause of aging in complex organisms resulting from recent advances in functional genomics and systems biology. - ;Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technolAgingGenetic aspectsGenomesAgingGenetic aspects.Genomes.571.878Vijg Jan1557209MiAaPQMiAaPQMiAaPQBOOK9910792273803321Aging of the genome3820563UNINA05724nam 22007454a 450 991101878140332120200520144314.09786611087890978128108789812810878909783527609444352760944X9783527609307352760930X(CKB)1000000000327285(EBL)481303(SSID)ssj0000231057(PQKBManifestationID)11194868(PQKBTitleCode)TC0000231057(PQKBWorkID)10198571(PQKB)11053755(MiAaPQ)EBC481303(PPN)249608731(OCoLC)86189676(Perlego)2766849(EXLCZ)99100000000032728520070906d2007 uy 0engur|n|---|||||txtccrQuality assurance in analytical chemistry applications in environmental, food, and materials analysis, biotechnology, and medical engineering /Werner Funk, Vera Dammann, Gerhild Donnevert2nd ed.Weinheim Wiley-VCHc20071 online resource (303 p.)Translated from the German.9783527311149 3527311149 Includes bibliographical references (p. 209-217) and index.Quality Assurance in Analytical Chemistry; Contents; Preface to the Second Edition; Preface to the First Edition; List of Symbols; 0 Introduction; 0.1 General Differentiation of Analytical Processes; 0.2 Quality of Analytical Processes and Results; 0.3 The System of Analytical Quality Assurance; 0.4 The Four-Phase Model of Analytical Quality Assurance; 1 Phase I: Establishing a New Analytical Procedure; 1.1 Introduction; 1.1.1 Objectives of Phase I; 1.1.2 When Are Characteristic Data Obtained?; 1.1.3 The Progression of Phase I; 1.1.4 Results of Phase I; Statistical Data1.2 Calibration of the Fundamental Analytical Procedure (Fundamental Calibration)1.2.1 Establishment of an Analytical Range; 1.2.2 Preparation of Standard Samples; 1.2.3 Determination of the Calibration Function and Process Data; 1.2.3.1 Process Data for the Linear Calibration Function; 1.2.3.2 Process Data for the Second-Order Calibration Function; 1.2.3.3 Calculating Analytical Results with the Aid of the Calibration Function; 1.2.4 Verification of the Fundamental Calibration; 1.2.4.1 Verification of Linearity; 1.2.4.2 Verification of Precision; 1.3 Analyses at Very Low Concentrations1.3.1 Decision Limit [34, 120, 132]1.3.2 Determining the Minimum Detectable Value [34, 120]; 1.3.2.1 Minimum Detectable Value, Determined Using the Distribution of Blank Values; 1.3.2.2 Minimum Detectable Value, Obtained Using the Calibration Function; 1.3.3 Limit of Quantification [34]; 1.3.4 Quick Estimation; 1.3.5 Estimation of the Decision Limit and Limit of Quantification Using the S/N Ratio; 1.4 Validation of Individual Process Steps and Examination of Matrix Influences; 1.4.1 Systematic Errors; 1.4.1.1 Constant Systematic Errors, Additive Deviations1.4.1.2 Proportional Systematic Errors, Multiplicative Deviations1.4.2 Establishment and Assessment of the Recovery Function; 1.4.2.1 Prerequisites for the Interpretation of the Recovery Function; 1.4.2.2 Testing for Systematic Errors; 1.4.3 Application of the Recovery Function; 1.4.3.1 Checking Individual Process Steps; 1.4.3.2 Determination of the Recovery Function to Prove the Influence of a Matrix; 1.5 Additional Statistical Methods; 1.6 Use of Internal Standards [50]; 1.6.1 Definition, Purpose; 1.6.2 Conditions and Limitations of the Use of Internal Standards; 1.6.3 Procedure1.7 Preparing for Routine Analysis1.7.1 Examination of the Time Dependency of Measured Values; 1.7.1.1 Comparison of the "Within Batch" Standard Deviation (s(w)) with the "Between Batches" Standard Deviation (s(b)) [215]; 1.7.1.2 Determining the Need for Daily Adjustment of Analytical Equipment; 1.7.1.3 The Trend Test; 1.8 Summary of the Results of Phase I (Process Development): Documentation; 2 Phase II: An Analytical Process Becomes Routine; Preparative Quality Assurance; 2.1 Introduction; 2.1.1 Objective of Phase II; 2.1.2 Execution of Phase II; 2.1.3 Progression of Phase II2.1.4 Results of Phase IIThis best-selling title both in German and English is now enhanced by a new chapter on the important topical subject of measurement uncertainty, plus a CD-ROM with interactive examples in the form of Excel-spreadsheets. These allow readers to gain an even better comprehension of the statistical procedures for quality assurance while also incorporating their own data.Following an introduction, the text goes on to elucidate the 4-phase model of analytical quality assurance: establishing a new analytical process, preparative quality assurance, routine quality assurance and external analyticalChemical laboratoriesQuality controlAnalytical chemistryQuality controlAnalytical chemistryTechniqueChemical laboratoriesQuality control.Analytical chemistryQuality control.Analytical chemistryTechnique.540543.0685Funk Werner1944-1996.1841636Dammann Vera1839961Donnevert Gerhild1839962MiAaPQMiAaPQMiAaPQBOOK9911018781403321Quality assurance in analytical chemistry4421452UNINA