01026cam0-22003251i-450-99000685491040332120071009120641.088-464-0264-2000685491FED01000685491(Aleph)000685491FED0100068549120010426d1997----km-y0itay50------baitaITy-------001yy<<La >>comunicazione d'impresa e la promozione dell'immaginemetodi e tecniche per lo sviluppo, la pianificazione e laverifica della comunicazioneMarcello MorelliMilanoFrancoAngeli1997160 p.23 cmAzienda moderna339Relazioni pubbliche659.221itaMorelli,Marcello106324ITUNINARICAUNIMARCBK990006854910403321Collez. 684 (339)31304FSPBCFSPBCComunicazione d'impresa e la promozione dell'immagine624692UNINA05429nam 22006974a 450 991014332020332120190716161830.01-280-74871-097866107487160-470-76390-60-470-98880-01-4051-7306-8(CKB)1000000000341826(EBL)284293(OCoLC)437176167(SSID)ssj0000222339(PQKBManifestationID)11910861(PQKBTitleCode)TC0000222339(PQKBWorkID)10174167(PQKB)10086603(MiAaPQ)EBC284293(EXLCZ)99100000000034182620060210d2006 uy 0engur|n|---|||||txtccrPlant hormone signaling[electronic resource] /edited by Peter Hedden and Stephen G. ThomasOxford, UK ;Ames, Iowa Blackwell Pub.20061 online resource (370 p.)Annual plant reviews ;24Description based upon print version of record.1-4051-3887-4 Includes bibliographical references and index.Plant Hormone Signaling; Contents; Contributors; Preface; 1 Abscisic acid synthesis, metabolism and signal transduction; 1.1 Introduction; 1.2 Biosynthesis and catabolism pathways; 1.2.1 Main early steps of ABA biosynthesis; 1.2.2 Epoxy-carotenoid cleavage; 1.2.3 The conversion of xanthoxin to ABA; 1.2.4 ABA catabolism; 1.3 Regulation of ABA synthesis and metabolism; 1.3.1 Developmental regulation; 1.3.1.1 Vegetative tissues; 1.3.1.2 Reproductive organs; 1.3.2 Regulation in response to abiotic stresses; 1.3.3 Regulation by endogenous signals and factors1.4 ABA signaling in seed maturation processes: proteolysis and combinatorial protein interactions1.5 Stress responses in vegetative tissues: the five major nexuses; 1.5.1 ABA recognition sites and the search for the receptors; 1.5.2 Transcriptional network as the readout; 1.5.3 RNA metabolism; 1.5.4 Protein phosphatases 2C; 1.5.5 Sucrose non-fermenting-related kinases; 1.6 ABA signaling in guard cells: simple movements controlled by complex mechanisms; 1.7 ABA as antagonizing signal to light in stomatal movement; 1.8 Concluding remarks; Acknowledgements; References2 Auxin metabolism and signaling2.1 Introduction; 2.2 Auxin metabolism; 2.2.1 Indole-3-acetic acid biosynthesis; 2.2.1.1 The tryptophan-independent pathway; 2.2.1.2 IAA biosynthesis from tryptophan; 2.2.2 IAA conjugates in plants; 2.2.2.1 IAA-peptide conjugates; 2.2.2.2 Amino acid conjugates; 2.2.2.3 Amide conjugate hydrolysis; 2.2.2.4 Ester conjugates; 2.2.3 IAA degradation; 2.3 Auxin signaling; 2.3.1 Auxin-responsive genes; 2.3.2 Auxin response factors; 2.3.3 Regulation of auxin response by the SCFTIR1 ubiquitin-ligase; 2.3.4 Regulation of SCFTIR1 activity2.3.5 Identification of an auxin receptor2.4 Conclusions and future perspectives; Acknowledgements; References; 3 Integration of brassinosteroid biosynthesis and signaling; 3.1 Introduction; 3.2 Metabolism; 3.2.1 Biosynthesis; 3.2.1.1 DET2; 3.2.1.2 SAX1; 3.2.1.3 DWF4; 3.2.1.4 CPD; 3.2.1.5 ROT3 and CYP90D1; 3.2.1.6 CYP85A1 and CYP85A2; 3.2.1.7 Other biosynthetic functions; 3.2.2 Inactivation; 3.2.2.1 BAS1; 3.2.2.2 CHI2/SHK1/SOB7; 3.2.2.3 UGT73C5; 3.2.2.4 BNST3 and BNST4; 3.2.3 Functional aspects of BR metabolism; 3.2.3.1 Regulation of biosynthetic genes3.2.3.2 Regulation of BR-inactivating genes3.2.3.3 Conservation of BR synthesis in higher plants; 3.3 Signal transduction; 3.3.1 BRI1 and BAK1; 3.3.2 BIN2 and BSU1; 3.3.3 BZR1 and BZR2/BES1; 3.3.4 BIM1; 3.3.5 Signaling mechanism and other putative components; 3.4 Future prospectives; 3.4.1 Metabolism; 3.4.2 Signal transduction; 3.4.3 Crops; Acknowledgements; References; 4 Cytokinin metabolism and signal transduction; 4.1 Introduction; 4.2 Cytokinin metabolism; 4.2.1 Cytokinin biosynthesis; 4.2.2 Cytokinin interconversion and conjugation; 4.2.3 Cytokinin catabolism4.3 Cytokinin signal transductionPlant growth is regulated by developmental programmes that can be modified by environmental cues acting through endogenous signaling molecules including plant hormones.This volume provides an overview of the biosynthesis, catabolism, perception and signal transduction of the individual hormone classes, followed by chapters on hormone distribution and transport, and the roles of hormone signaling in specific developmental processes. Particular attention is paid to the regulation of hormone signaling by environmental and developmental cues, sites of hormone metabolism and action, and intAnnual plant reviews ;v. 24.Plant hormonesPlant cellular signal transductionElectronic books.Plant hormones.Plant cellular signal transduction.571.742580.542.42bclHedden Peter896556Thomas Stephen G(Stephen Gregory),1969-896557Wiley Online Library (Servicio en línea)MiAaPQMiAaPQMiAaPQBOOK9910143320203321Plant hormone signaling2003111UNINA05297nam 2200673Ia 450 991013919210332120170810191416.01-118-03512-71-282-68335-797866126833500-470-62272-50-470-62271-7(CKB)2560000000011999(EBL)543002(OCoLC)645098676(SSID)ssj0000413479(PQKBManifestationID)11299772(PQKBTitleCode)TC0000413479(PQKBWorkID)10381118(PQKB)11221945(PQKBManifestationID)16524544(PQKB)23042129(MiAaPQ)EBC543002(DLC) 2016299616(EXLCZ)99256000000001199920091203d2010 uy 0engur|n|---|||||txtccrCancer risk assessment[electronic resource] chemical carcinogenesis, hazard evaluation, and risk quantification /edited by Ching-Hung Hsu, Todd StedefordHoboken, N.J. Wileyc20101 online resource (858 p.)Description based upon print version of record.0-470-23822-4 Includes bibliographical references and index.CANCER RISK ASSESSMENT: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification; CONTENTS; PREFACE; CONTRIBUTORS; ABBREVIATIONS AND ACRONYMS; PART I: CANCER RISK ASSESSMENT, SCIENCE POLICY, AND REGULATORY FRAMEWORKS; CHAPTER 1: CANCER RISK ASSESSMENT; CHAPTER 2: SCIENCE POLICY AND CANCER RISK ASSESSMENT; CHAPTER 3: HAZARD AND RISK ASSESSMENT OF CHEMICAL CARCINOGENICITY WITHIN A REGULATORY CONTEXT; CHAPTER 4: USE OF CANCER RISK ASSESSMENTS IN DETERMINATION OF REGULATORY STANDARDS; PART II: CANCER BIOLOGY AND TOXICOLOGY; CHAPTER 5: THE INTERPLAY OF CANCER AND BIOLOGYCHAPTER 6: CHEMICAL CARCINOGENESIS: A BRIEF HISTORY OF ITS CONCEPTS WITH A FOCUS ON POLYCYCLIC AROMATIC HYDROCARBONSCHAPTER 7: HORMESIS AND CANCER RISKS: ISSUES AND RESOLUTION; CHAPTER 8: THRESHOLDS FOR GENOTOXIC CARCINOGENS: EVIDENCE FROM MECHANISM-BASED CARCINOGENICITY STUDIES; PART III: GENETIC TOXICOLOGY, TESTING GUIDELINES AND REGULATIONS, AND NOVEL ASSAYS; CHAPTER 9: DEVELOPMENT OF GENETIC TOXICOLOGY TESTING AND ITS INCORPORATION INTO REGULATORY HEALTH EFFECTS TEST REQUIREMENTS; CHAPTER 10: GENETIC TOXICOLOGY TESTING GUIDELINES AND REGULATIONS; CHAPTER 11: IN VITRO GENOTOX ASSAYSCHAPTER 12: IN VIVO GENOTOXICITY ASSAYSPART IV: ASSESSING THE HUMAN RELEVANCE OF CHEMICAL-INDUCED TUMORS; CHAPTER 13: FRAMEWORK ANALYSIS FOR DETERMINING MODE OF ACTION AND HUMAN RELEVANCE; CHAPTER 14: EXPERIMENTAL ANIMAL STUDIES AND CARCINOGENICITY; CHAPTER 15: CANCER EPIDEMIOLOGY; CHAPTER 16: RODENT HEPATOCARCINOGENESIS; CHAPTER 17: MODE OF ACTION ANALYSIS AND HUMAN RELEVANCE OF LIVER TUMORS INDUCED BY PPAR a ACTIVATION; CHAPTER 18: ALPHA 2U-GLOBULIN NEPHROPATHY AND CHRONIC PROGRESSIVE NEPHROPATHY AS MODES OF ACTION FOR RENAL TUBULE TUMOR INDUCTION IN RATS, AND THEIR POSSIBLE INTERACTIONCHAPTER 19: URINARY TRACT CALCULI AND BLADDER TUMORSPART V: METHODS FOR INFORMING CANCER RISK QUANTIFICATION; CHAPTER 20: (Q) SAR ANALYSIS OF GENOTOXIC AND NONGENOTOXIC CARCINOGENS: A STATE-OF-THE-ART OVERVIEW; CHAPTER 21: PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELS IN CANCER RISK ASSESSMENT; CHAPTER 22: GENOMICS AND ITS ROLE IN CANCER RISK ASSESSMENT; CHAPTER 23: COMPUTATIONAL TOXICOLOGY IN CANCER RISK ASSESSMENT; PART VI: GENERAL APPROACHES FOR QUANTIFYING CANCER RISKS; CHAPTER 24: LINEAR LOW-DOSE EXTRAPOLATIONSCHAPTER 25: QUANTITATIVE CANCER RISK ASSESSMENT OF NONGENOTOXIC CARCINOGENSCHAPTER 26: NONLINEAR LOW-DOSE EXTRAPOLATIONS; CHAPTER 27: CANCER RISK ASSESSMENT: MORE UNCERTAIN THAN WE THOUGHT; CHAPTER 28: COMBINING NEOPLASMS FOR EVALUATION OF RODENT CARCINOGENESIS STUDIES; CHAPTER 29: CANCER RISK BASED ON AN INDIVIDUAL TUMOR TYPE OR SUMMING OF TUMORS; CHAPTER 30: EXPOSURE RECONSTRUCTION AND CANCER RISK ESTIMATE DERIVATION; INDEX"With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous"--Provided by publisher.CarcinogensHealth risk assessmentElectronic books.Carcinogens.Health risk assessment.616.99/4071616.994071Hsu Ching-Hung874014Stedeford Todd874015MiAaPQMiAaPQMiAaPQBOOK9910139192103321Cancer risk assessment1951486UNINA