01006cam0-2200337---450-99000474555040332120100419095206.0000474555FED01000474555(Aleph)000474555FED0100047455519990604d1925----km-y0itay50------baitaITy-------001yyMiti, leggende e superstizioni del Medio Evoil mito del paradiso terrestre. Il riposo dei dannati. La credenza nella fatalità [...]TorinoChiantore1925XIX, 530 p.25 cmMitiMedioevoLeggendeMedioevo398.2Graf,Arturo<1848-1913 >90702ITUNINARICAUNIMARCBK990004745550403321398.2 GRA 2R. Bibl. 8341FLFBCBIB. BAT.1408BATFLFBCBATMiti, leggende e superstizioni del medio evo89075UNINA04505nam 2201201z- 450 991055760740332120210501(CKB)5400000000045328(oapen)https://directory.doabooks.org/handle/20.500.12854/68520(oapen)doab68520(EXLCZ)99540000000004532820202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNovel Natural-based Biomolecules Discovery for Tackling Chronic DiseasesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (180 p.)3-0365-0386-2 3-0365-0387-0 Natural-based biomolecules continuously play an important role in novel drug discovery for the treatment of chronic diseases. The development of natural peptide/protein-based, toxin-based, and antibody-based drugs can significantly improve the biomedical efficiency of disease-specific therapy. The focus of this Special Issue of Biomolecules will be on the most recent advances related to novel peptides/proteins, antibodies, and toxins as forms of medicinal therapy. Recent advances in the discovery and development of these natural biomolecules for use in targeted therapy and immunotherapy against chronic diseases (e.g., cancer, diabetes, cardiovascular diseases, and rheumatoid arthritis) will be addressed. The discussion on using novel disease-specific proteins/peptides/toxins/antibodies along with currently available FDA-approved drugs as combinatorial treatments will also be encouraged in this context. Finally, an overview of some of the selected promising natural biomolecules that are potentially able to address the forthcoming challenges in this field will be included. Both research (in particular) and review articles proposing novelties or overviews, respectively, are welcome.HumanitiesbicsscSocial interactionbicsscAKTamphibian Bowman-Birk inhibitoramyloidogenesisanionic lipidsanti-inflammationanticancer therapyanticancer therapy/cancer treatmentantifungalantioxidantapoptosisAsteraceaeAstragalus membranaceusBcl-2 family proteinsbinding affinitybranched-chain fatty acidscell cycle arrestcolorectal cancerConidiobolus heterosporusCOX-2DAPK1docetaxeldrug delivery systemdrug designendoplasmic reticulumF23R variantfatty acid oxidationfibroblastsfucoidanG-protein activationgingivahepatocytehIAPPiNOSinsulininsulin granuleskynurenineslignanlipid metabolismlung cancermolecular cloningmolecular dockingn/anatural-based compoundNOorientinPDX-1peptidesperoxisome proliferator-activated receptor αPetasites japonicusPGE2pharmacophorePI3KPLGApomegranatepost-translational modificationPPARγprotease inhibitorprotein degradationpunicalaginSENPSTAT3SUMOsurvivintanninsTat peptideunfolded protein responsewound healingβ-cell cytotoxicityβ-sheet transitionsμ-opioid receptorHumanitiesSocial interactionKwok Hang Faiedt1310431Kwok Hang FaiothBOOK9910557607403321Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases3039486UNINA