01166nam0 22002893i 450 VAN011076620170919102144.20488-453-0552-X20170919d1992 |0itac50 baitaIT|||| |||||ˆIl ‰progetto del designper una didattica del disegno industrialeAntonio D'Auria, Renato De FuscoMilanoETAS libri1992XIII, 465 p.ill.24 cm.001VAN01107702001 Comunicazione210 MilanoEtas.Disegno industrialeVANC033194ARMilanoVANL000284D'AuriaAntonioVANV02292010614De FuscoRenatoVANV0126362251Etas <editore>VANV108308650ITSOL20230616RICABIBLIOTECA DEL DIPARTIMENTO DI ARCHITETTURA E DISEGNO INDUSTRIALEIT-CE0107VAN01VAN0110766BIBLIOTECA DEL DIPARTIMENTO DI ARCHITETTURA E DISEGNO INDUSTRIALE01PREST IIAd53 01 52690 20170919 Progetto del design714934UNICAMPANIA05281nam 22006374a 450 991083022410332120170815113943.01-281-13531-397866111353170-470-51743-30-470-51744-1(CKB)1000000000413971(EBL)326413(OCoLC)476124182(SSID)ssj0000176759(PQKBManifestationID)11170150(PQKBTitleCode)TC0000176759(PQKBWorkID)10206033(PQKB)10010364(MiAaPQ)EBC326413(PPN)188664904(EXLCZ)99100000000041397120070604d2007 uy 0engur|n|---|||||txtccrIminosugars[electronic resource] from synthesis to therapeutic applications /editors, Philippe Compain and Olivier R. MartinChichester, West Sussex, England ;Hoboken, NJ, USA J. Wileyc20071 online resource (487 p.)Description based upon print version of record.0-470-03391-6 Includes bibliographical references and index.Iminosugars; Contents; Foreword; Preface; List of contributors; 1 Iminosugars: past, present and future; 2 Naturally occurring iminosugars and related alkaloids: structure, activity and applications; 2.1 Introduction; 2.2 -Glucosidase inhibitors; 2.3 -Glucosidase inhibitors; 2.4 - and -Galactosidase inhibitors; 2.5 -Mannosidase inhibitors; 2.6 Concluding remarks and future prospects; References; 3 General strategies for the synthesis of iminosugars and new approaches towards iminosugar libraries; 3.1 Introduction; 3.2 Monocyclic compounds; 3.3 1-N-Iminosugars; 3.4 Bicyclic compounds3.5 Other bicyclic compounds3.6 Iminosugar conjugates; 3.7 Conclusions; References; 4 Iminosugar C-glycosides: synthesis and biological activity; 4.1 Introduction; 4.2 Synthesis of iminosugar C-glycosides; 4.3 Biological activity of iminosugar C-glycosides; 4.4 Conclusion; References; 5 Imino-C-disaccharides and analogues: synthesis and biological activity; 5.1 Introduction; 5.2 Synthesis of imino-C-disaccharides; 5.3 Conformations of imino-C-disaccharides; 5.4 Glycosidase inhibitory activities of imino-C-disaccharides5.5 Efficient combinatorial method for the discovery of glycosidase inhibitors5.6 Antitumour activity of new -mannosidase inhibitors; 5.7 Conclusion; References; 6 Isofagomine, noeuromycin and other 1-azasugars, iminosugar-related glycosidase inhibitors; 6.1 Introduction; 6.2 1-Azasugars that are piperidines (isofagomine, noeuromycin, etc.); 6.3 1-Azasugars that are hydrazines; 6.4 1-Azasugars that are oxazines; 6.5 1-Azasugars that are piperidones; 6.6 Sulphur-containing analogues of 1-azasugars; 6.7 Slow inhibition and thermodynamics of binding6.8 Are 1-azasugars (and iminosugars) transition state analogues?References; 7 Iminosugar-based glycosyltransferase inhibitors; 7.1 Biological role and structural features of glycosyltransferases; 7.2 Development of inhibitors of glycosyltransferases; 7.3 Conclusion; References; 8 Transition state analogue inhibitors of N-ribosyltransferases; 8.1 Introduction; 8.2 Nucleoside hydrolases; 8.3 Purine nucleoside phosphorylases (PNPs); 8.4 5'-Methylthioadenosine (MTA) nucleosidases and phosphorylases; 8.5 Ricin A-chain; References; 9 Iminosugars as antiviral agents; 9.1 Introduction9.2 The relationship between glucosidase inhibition and antiviral action9.3 Fate of viral glycoproteins in glucosidase-inhibited cells; 9.4 Specificity of glucosidase inhibition; 9.5 N-Alkyl DNJs inhibit virus growth by non-glucosidase inhibitory mechanisms - other potential activities of these compounds; 9.6 New directions for improving glucosidase inhibitors as antiviral agents; References; 10 Iminosugars as active-site-specific chaperones for the treatment of lysosomal storage disorders; 10.1 Introduction; 10.2 Degradation of glycosphingolipids10.3 Lysosomal enzyme biosynthesis and ER-associated degradation (ERAD)Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970's, these polyvalent molecules have progressively made their way from the laboratory to the clinic. The impressive series of discoveries in the field over the past ten years indicates clearly that it is "a boom time" for iminosugarImino sugarsSynthesisImino sugarsTherapeutic useImino sugarsSynthesis.Imino sugarsTherapeutic use.572.565612/.01578Compain Philippe1663703Martin Olivier R1663704MiAaPQMiAaPQMiAaPQBOOK9910830224103321Iminosugars4021215UNINA01731nas 2200481-a 450 99632171500331620240207220139.0(DE-599)ZDB1427642-2(OCoLC)51832817(CKB)111092941545008(CONSER)--2004208634(EXLCZ)9911109294154500820030311a19989999 s-- -gerurcnu||||||||txtrdacontentcrdamediacrrdacarrierLinguistik onlineFrankfurt (Oder) Kulturwissenschaftlichen Fakultät an der Europa-Universität Viadrina in Frankfurt (Oder)1998-Refereed/Peer-reviewedEach issue has also a thematic title.Title from home page (publisher's Web site, viewed Mar. 5, 2003).1615-3014 Publication focuses on research in: conversation analysis, history of language, language acquisition, linguistic history, theory and methods, morphology and syntax, pragmatics, semantics, and sociolinguistics.LinguisticsPeriodicalsLinguisticsfast(OCoLC)fst00999202LinguistikgndZeitschriftgndOnline-RessourcegndOnline-PublikationswdPeriodicals.fastLinguisticsLinguistics.LinguistikZeitschriftOnline-RessourceOnline-Publikation.Europa-Universität Viadrina Frankfurt an der Oder.Kulturwissenschaftliche Fakultät.JOURNAL996321715003316Linguistik online2124793UNISA