01605nam0 22003613i 450 VAN007486620230719094648.46488-86202-00-820100330d1995 |0itac50 baitaIT|||| |||||Codice delle leggi speciali ed antimafia in materia di misure di prevenzionecoordinate ed integrate con le norme complementari ed annotate con la giurisprudenzaPaolo CelentanoBolognaPragma1995XVIII, 525 p.17 cmVAN0080579Codice delle leggi in materia di misure di prevenzioneMafiaLegislazione penaleVANC001190FIMisure di prevenzioneLegislazioneVANC027297FIBolognaVANL000003345.4505221CelentanoPaoloVANV061455ItaliaVANV001942423419PragmaVANV109909650Repubblica italianaItaliaVANV057868Regno d'Italia <1861-1946>ItaliaVANV057870Italia <Regno ; 1861-1946>ItaliaVANV057871Italia <Repubblica ; 1946- >ItaliaVANV057873ITSOL20230721RICABIBLIOTECA DEL DIPARTIMENTO DI GIURISPRUDENZAIT-CE0105VAN00VAN0074866BIBLIOTECA DEL DIPARTIMENTO DI GIURISPRUDENZA00CONS XIV.B.26 00FT 35742 20100330 Fondo TribunaleCodice delle leggi speciali ed antimafia in materia di misure di prevenzione1419360UNICAMPANIA04236nam 2200493 450 991068824080332120231214145408.0(CKB)3710000000631111(oapen)https://directory.doabooks.org/handle/20.500.12854/54519(EXLCZ)99371000000063111120160411d2016 c0 0engur||#---uu|||txtrdacontentcrdamediacrrdacarrierNeuronal self-defense compensatory mechanisms in neurodegenerative disorders /edited by: Rosanna Parlato and Pier Giorgio MastroberardinoFrontiers Media SA2016[Lausanne, Switzerland] :Frontiers Media SA,2016.©20161 online resource (190 pages) illustrations; digital file(s)Frontiers Research TopicsFrontiers in Cellular Neuroscience.2-88919-759-X Includes bibliographical references.Neurodegenerative disorders are characterized by the progressive loss of specific populations of neurons with consequent deterioration of brain’s function and dramatic impact on human behavior. At present, there are no effective cures for neurodegenerative diseases. Because unambiguous diagnosis is possible only after manifestation of symptoms, when a large proportion of neurons has been already lost, therapies are necessarily confined to alleviation of symptoms. Development of cures halting the disease course is hampered by our rudimentary understanding of the etiopathology. Most neurodegenerative disorders are sporadic and age-related and - even for those of known genetic origin - the mechanisms influencing disease onset and progression have not been fully characterized. The different diseases, however, share important similarities in the mechanisms responsible for neuronal loss, which is caused by a combination of endogenous and exogenous challenges. Trophic deprivation, oxidative stress, accumulation of abnormal protein aggregates, and bioenergetics defects have been described in most, if not all, neurodegenerative disease.To counterbalance these noxious stimuli cells deploy, at least during the initial pathogenic states, intrinsic neuroprotective responses. These are general compensatory mechanisms, common to several neurodegenerative conditions, which reprogram cellular physiology to overcome stress. Adaptation includes strategies to optimize energetic resources, for instance reduction of rRNA synthesis to repress translation, suppression of transcription, and bioenergetics and metabolic redesign. Additional mechanisms include potentiation of antioxidant capacity, induction of endoplasmic reticulum (ER) stress, and activation of protein quality control systems and autophagy. Ineffective execution of these compensatory strategies severely threatens cellular homeostasis and favors onset of pathology. Therefore, a better understanding of these “buffering” mechanisms and of their interconnections may help to devise more effective therapeutic tools to prolong neuronal survival and activity, independently of the original genetic mutations and stress insults.This Research Topic focuses on the initial compensatory responses protecting against failure of those mechanisms that sustaining neuronal survival and activity. The collection intends to summarize the state-of-the-art in this field and to propose novel research contributes, with the ultimate goal of inspiring novel studies aimed to contrast progression of neurodegenerative diseases.Frontiers research topics.Nervous systemDegenerationResearchNeuropsychiatrymodelsstress responseCompensationmechanismstranNeurodegenerative disordersNervous systemDegenerationResearch.Neuropsychiatry.Parlato RosannaMastroberardino Pier GiorgioFrontiers Research Foundation,BOOK9910688240803321Neuronal self-defense3122485UNINA