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INDIANO - LETTERATURA HINDI - MODERNA E CONTEMPORANEA - NARRATIVAAVIVEKIRAYAUONV040305Chinmaya PrakashanaUONV263979650VIVEKIRAYVIVEKIRAYAUONV092489RAY, VivekiVIVEKIRAYAUONV040738ITSOL20240220RICASIBA - SISTEMA BIBLIOTECARIO DI ATENEOUONSIUON00063757SIBA - SISTEMA BIBLIOTECARIO DI ATENEOSI SI VI CCX 248 SI SA 35030 5 248 Vandemataram1171812UNIOR01305nam0 22002893i 450 VAN0026621920240806101519.988979-12-211-0195-920231106d2023 |0itac50 baitaIT|||| |||||Traditio all'estero e controlli in CassazioneMarco PittirutiTorinoGiappichelli2023VII, 157 p.24 cm001VAN001014942001 Processo penale e politica criminale210 TorinoGiappichelli.22VAN00267668Traditio all'estero e controlli in Cassazione3395863TorinoVANL000001PittirutiMarcoVANV219261758885Giappichelli <editore>VANV107921650ITSOL20240906RICAhttps://www.giappichelli.it/media/catalog/product/summary/9791221101959.pdfhttps://www.giappichelli.it/media/catalog/product/summary/9791221101959.pdfBIBLIOTECA DEL DIPARTIMENTO DI GIURISPRUDENZAIT-CE0105VAN00VAN00266219BIBLIOTECA DEL DIPARTIMENTO DI GIURISPRUDENZA00CONS XIV.El.124 00UBG9288 20231106 Traditio all'estero e controlli in cassazione3395863UNICAMPANIA04835nam 2200769Ia 450 991095314660332120200520144314.09786611237417978128123741512812374189780470249031047024903X97804702490240470249021(CKB)1000000000401090(EBL)333797(OCoLC)476138555(SSID)ssj0000226315(PQKBManifestationID)11235959(PQKBTitleCode)TC0000226315(PQKBWorkID)10257897(PQKB)10882296(MiAaPQ)EBC333797(Au-PeEL)EBL333797(CaPaEBR)ebr10226748(CaONFJC)MIL123741(OCoLC)176895587(FINmELB)ELB177538(Perlego)2773560(EXLCZ)99100000000040109020080125d2008 uy 0engur|n|---|||||rdacontentrdamediardacarrierPreclinical development handbookADME and biopharmaceutical properties /[edited by] Shayne Cox Gad1st ed.Hoboken, N.J. Wiley-Intersciencec20081 online resource (1347 p.)Pharmaceutical Development Series ;v.3Description based upon print version of record.9780470248478 0470248475 Includes bibliographical references and index.PRECLINICAL DEVELOPMENT HANDBOOK ADME and Biopharmaceutical Properties; CONTRIBUTORS; CONTENTS; Preface; 1 Modeling and Informatics in Drug Design; 2 Computer Techniques: Identifying Similarities Between Small Molecules; 3 Protein-Protein Interactions; 4 Method Development for Preclinical Bioanalytical Support; 5 Analytical Chemistry Methods: Developments and Validation; 6 Chemical and Physical Characterizations of Potential New Chemical Entity; 7 Permeability Assessment; 8 How and Where Are Drugs Absorbed?; 9 Absorption of Drugs after Oral Administration10 Distribution: Movement of Drugs through the Body11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution; 12 Transporter Interactions in the ADME Pathway of Drugs; 13 Accumulation of Drugs in Tissues; 14 Salt and Cocrystal Form Selection; 15 Dissolution; 16 Stability: Physical and Chemical; 17 Dosage Formulation; 18 Cytochrome P450 Enzymes; 19 Metabolism Kinetics; 20 Drug Clearance; 21 In Vitro Metabolism in Preclinical Drug Development; 22 Utilization of In Vitro Cytochrome P450 Inhibition Data for Projecting Clinical Drug-Drug Interactions23 In Vivo Metabolism in Preclinical Drug Development24 In Vitro Evaluation of Metabolic Drug-Drug Interactions: Scientific Concepts and Practical Considerations; 25 Mechanisms and Consequences of Drug-Drug Interactions; 26 Species Comparison of Metabolism in Microsomes and Hepatocytes; 27 Metabolite Profiling and Structural Identification; 28 Linkage between Toxicology of Drugs and Metabolism; 29 Allometric Scaling; 30 Interrelationship between Pharmacokinetics and Metabolism; 31 Experimental Design Considerations in Pharmacokinetic Studies; 32 Bioavailability and Bioequivalence Studies33 Mass Balance Studies34 Pharmacodynamics; 35 Physiologically Based Pharmacokinetic Modeling; 36 Mathematical Modeling as a New Approach for Improving the Efficacy/Toxicity Profile of Drugs: The Thrombocytopenia Case Study; 37 Regulatory Requirements for INDs/FIH (First in Human) Studies; 38 Data Analysis; IndexA clear, straightforward resource to guide you through preclinical drug developmentFollowing this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques.Each chapter is written by one or more leadinPharmaceutical Development SeriesADME and biopharmaceutical propertiesPharmacokineticsHandbooks, manuals, etcDrug developmentHandbooks, manuals, etcPharmacokineticsDrug development615.1901615.7615/.7Gad Shayne C.1948-96171MiAaPQMiAaPQMiAaPQBOOK9910953146603321Preclinical development handbook4367994UNINA05563oam 22012974 450 991096582410332120250426110030.097866128424059781462321476146232147X978145274200714527420069781451871654145187165197812828424031282842404(CKB)3170000000055177(EBL)1608132(SSID)ssj0000942989(PQKBManifestationID)11505577(PQKBTitleCode)TC0000942989(PQKBWorkID)10974939(PQKB)10067310(OCoLC)469097802(IMF)WPIEE2009018(MiAaPQ)EBC1608132(IMF)WPIEA2009018WPIEA2009018(EXLCZ)99317000000005517720020129d2009 uf 0engur|n|---|||||txtccrOn Impatience and Policy Effectiveness /Silvia Sgherri, Tamim Bayoumi1st ed.Washington, D.C. :International Monetary Fund,2009.1 online resource (30 p.)IMF Working PapersDescription based upon print version of record.9781451916010 1451916019 Includes bibliographical references.Contents; I. Introduction; II. Theoretical Model; III. Empirical Estimates; IV. Analysis and Discussion; V. Conclusions and Policy Implications; References; Tables; 1. United States: Unit Root Tests; 2. United States: Cointegration Tests; 3. United States: Estimates of Unrestricted Model (Eq. 10); 4. United States: Estimates of Restricted Model with Impatient Consumers (Eq. 9); Figures; 1. United States: The Data, 1955-2005; 2. United States: Validity of Model Restrictions over Time; 3. United States: Time Variation in the Discount Wedge4. United States: Time Variation in the Persistence of Income/Policy Shocks5. United States: Time Variation in Income/Policy Multiplier; 6. United States: Counterfactual AnalysisAn increasing body of evidence suggests that the behavior of the economy has changed in many fundamental ways over the last decades. In particular, greater financial deregulation, larger wealth accumulation, and better policies might have helped lower uncertainty about future income and lengthen private sectors' planning horizon. In an overlapping-generations model, in which individuals discount the future more rapidly than implied by the market rate of interest, we find indeed evidence of a falling degree of impatience, providing empirical support for this hypothesis. The degree of persistence of "windfall" shocks to disposable income also appears to have varied over time. Shifts of this kind are shown to have a key impact on the average marginal propensity to consume and on the size of policy multipliers.IMF Working Papers; Working Paper ;No. 2009/018Fiscal policyEconomic policyAggregate Factor Income DistributionimfBanks and BankingimfComparative or Joint Analysis of Fiscal and Monetary PolicyimfConsumptionimfEconomicsimfExpenditureimfExpenditures, PublicimfFinanceimfFinancial servicesimfIncomeimfInterest ratesimfInterest Rates: Determination, Term Structure, and EffectsimfMacroeconomicsimfMacroeconomics: ConsumptionimfNational accountsimfNational Government Expenditures and Related Policies: GeneralimfPersonal incomeimfPersonal Income, Wealth, and Their DistributionsimfPublic finance & taxationimfPublic FinanceimfReal interest ratesimfSavingimfStabilizationimfTreasury PolicyimfWealthimfUnited StatesimfFiscal policy.Economic policy.Aggregate Factor Income DistributionBanks and BankingComparative or Joint Analysis of Fiscal and Monetary PolicyConsumptionEconomicsExpenditureExpenditures, PublicFinanceFinancial servicesIncomeInterest ratesInterest Rates: Determination, Term Structure, and EffectsMacroeconomicsMacroeconomics: ConsumptionNational accountsNational Government Expenditures and Related Policies: GeneralPersonal incomePersonal Income, Wealth, and Their DistributionsPublic finance & taxationPublic FinanceReal interest ratesSavingStabilizationTreasury PolicyWealth339.5;339.52Sgherri Silvia1815869Bayoumi Tamim122763DcWaIMFBOOK9910965824103321On Impatience and Policy Effectiveness4372454UNINA