00906nam1 2200253 i 450 SUN006706220200305115017.9420.0020090129f |0itac50 baitaIT|||| |||||*Numerical methods in scientific computingGermund Dahlquist, Björck ÅkePhiladelphiaSIAMv.26 cm.001SUN00670612001 <<*Numerical methods in scientific computing>> 1Germund Dahlquist, Björck Åke1210 PhiladelphiaSIAMc2008215 XXVII, 717 p.26 cm.PhiladelphiaSUNL000037Dahlquist, GermundSUNV05327341208Björck, ÅkeSUNV0391260SIAMSUNV001157650ITSOL20200309RICASUN0067062Numerical methods in scientific computing45046UNICAMPANIA02141nam 2200457z- 450 991026114350332120210211(CKB)4100000002484657(oapen)https://directory.doabooks.org/handle/20.500.12854/43699(oapen)doab43699(EXLCZ)99410000000248465720202102d2017 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierComputational and Experimental Approaches in Multi-Target PharmacologyFrontiers Media SA20171 online resource (122 p.)Frontiers Research Topics9782889452521 2889452522 The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics.Pharmacologybicssccomputer modelingdrug combinationdrug discoverydrug repurposinghigh throughput screeningmultidrug therapeuticsmultifactorial processpolypharmacysynergysystems biologyPharmacologyAnastasio Thomas Jauth1797439BOOK9910261143503321Computational and Experimental Approaches in Multi-Target Pharmacology4339683UNINA