01326nam2 2200289 i 450 SUN006363220080402120000.008-983516-9-320080402d1999 |0engc50 baengUS|||| |||||ˆ70.1: ‰Johan Sadeler 1. Supplementby Isabelle de RamaixNew YorkAbaris books1999IX, 292 p.ill.31 cm.001SUN00373322001 The *illustrated Bartschgeneral editor: Walter L. Strauss[poi] founding editor Walter L. Straussgeneral editor John T. Spike70.1210 New YorkAbaris books215 volumiill.31 cm.SADELER, JOHANFISUNC024697USNew YorkSUNL000011Ramaix, Isabelle deSUNV050594611964Sadeler, Jan1550-ca.1600SUNV050595Abaris booksSUNV003351650ITSOL20181109RICASUN0063632UFFICIO DI BIBLIOTECA DEL DIPARTIMENTO DI LETTERE E BENI CULTURALI07 CONS Ne 1160 07 70993 UFFICIO DI BIBLIOTECA DEL DIPARTIMENTO DI LETTERE E BENI CULTURALIIT-CE010370993CONS Ne 1160caJohan Sadeler 1. Supplement1137962UNICAMPANIA04791nam 2200613Ia 450 991078001050332120230607213817.00-309-17086-91-280-18464-797866101846440-309-57011-5(CKB)111069351123168(EBL)3377445(SSID)ssj0000250579(PQKBManifestationID)11204740(PQKBTitleCode)TC0000250579(PQKBWorkID)10244692(PQKB)10867679(MiAaPQ)EBC3377445(Au-PeEL)EBL3377445(CaPaEBR)ebr10071474(CaONFJC)MIL18464(OCoLC)923270666(EXLCZ)9911106935112316820010815d2001 uy 0engur|n|---|||||txtccrStanding operating procedures for developing acute exposure guideline levels for hazardous chemicals[electronic resource] /Subcommittee on Acute Exposure Guideline Levels ...[et al.]Washington ;[England] National Academy Pressc20011 online resource (224 p.)Description based upon print version of record.0-309-07553-X Includes bibliographical references.""Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals""; ""Copyright""; ""Preface""; ""Contents""; ""Introduction""; ""REVIEW OF THE NAC DOCUMENT""; ""REFERENCES""; ""Roster National Advisory Committee for Acute Exposure Guideline Levels (NAC/AEGL Committee) for Hazardous Substances""; ""COMMITTEE MEMBERS""; ""Past Committee Members""; ""Participants from Cooperative Partner Countries""; ""Other Participants""; ""Oak Ridge National Laboratory Staff""; ""AEGL Program Senior Staff""; ""Appendix""; ""Preface""""1. Overview of AEGL Program and NAC/AEGL Committee""""HISTORY""; ""PURPOSE AND OBJECTIVES OF THE AEGL PROGRAM AND THE NAC/AEGL COMMITTEE""; ""COMMITTEE MEMBERSHIP AND ORGANIZATIONAL STRUCTURE""; ""SELECTION OF CHEMICALS FOR AEGL DEVELOPMENT""; ""SCIENTIFIC CREDIBILITY OF AEGL VALUES""; ""THE AEGL DEVELOPMENT AND PEER-REVIEW PROCESS""; ""Stage 1: Draft AEGLs""; ""Stage 2: Proposed AEGLs""; ""Stage 3: Interim AEGLs""; ""Stage 4: Final AEGLs""; ""OPERATION OF THE NAC/AEGL COMMITTEE""; ""VALUE OF A COLLABORATIVE EFFORT IN THE AEGL PROGRAM""; ""APPLICATIONS OF THE AEGL VALUES""""2. Derivation of AEGL Values""""2.1 CHARACTERIZATION OF AEGLS""; ""2.2 EMPIRICAL TOXICOLOGIC ENDPOINTS AND METHODS FOR DETERMINING EXPOSURE CONCENTRATIONS USED TO DERIVE AEGLS 1, 2, AND 3""; ""2.2.1 Selection of the Highest Exposure Level at Which the Effects That Define an AEGL Are Not Observed""; ""2.2.2 Selection of Health-Effect Endpoints for AEGL-1, AEGL-2, and AEGL-3""; ""2.2.2.1 AEGL-1 Endpoints""; ""2.2.2.1.1 No Value Establishedâ€?AEGL-1 Is Close to or Exceeds AEGL-2""; ""2.2.2.1.2 No Value Establishedâ€?Insufficient Data""""2.2.2.1.3 Highest Experimental Exposure Without an AEGL-1 Effect""""2.2.2.1.4 Effect Level for a Response""; ""2.2.2.2 AEGL-2 Endpoints""; ""2.2.2.2.1 Highest Experimental Exposure Without an AEGL-2 Effect""; ""2.2.2.2.2 Effect Level for a Toxic Response That Was Not Incapacitating or Not Irreversible""; ""2.2.2.2.3 A Fraction of the AEGL-3 Value""; ""2.2.2.3 AEGL-3 Endpoints""; ""2.2.2.3.1 Highest Exposure Level That Does Not Cause Lethalityâ€?Experimentally Observed Threshold (AEGL-3 NOAEL)""""2.2.2.3.2 Highest Exposure Level That Does Not Cause Lethalityâ€?Estimated Lethality Thresholdâ€?One-Third of the LC50""""2.2.2.3.3 Highest Exposure Level That Does Not Cause Lethalityâ€?Benchmark Exposure Calculation of the 5% and 1% Response""; ""2.2.2.3.4 Effect Level for a Response""; ""2.3 GUIDELINES AND CRITERIA FOR THE SEARCH STRATEGY, EVALUATION, SELECTION, AND DOCUMENTATION OF KEY DATA AND SUPPORTINGâ€?""; ""2.3.1 Search Strategy""; ""2.3.2 Evaluation, Selection, and Documentation of Key and Supporting Data""; ""2.3.3 Elements for Discussion on Data Adequacy and Research Needs""""2.4 DOSIMETRY CORRECTIONS FROM ANIMAL TO HUMAN EXPOSURES""Hazardous substancesRisk assessmentUnited StatesChemicalsPhysiological effectHazardous substancesRisk assessmentChemicalsPhysiological effect.363.1763MiAaPQMiAaPQMiAaPQBOOK9910780010503321Standing operating procedures for developing acute exposure guideline levels for hazardous chemicals3768219UNINA