01710nam0 2200349 i 450 SUN000544720120327114346.63988-07-47022-5IT99 149520020808d1998 |0itac50 baitaIT|||| |||||Diritti umani e democrazia cosmopolitica[scritti di] Daniele Archibugi, David Beethamcon un'appendice delle dichiarazioni storiche a cura di Mathias Koenig-ArchibugiMilano : Feltrinelli1998163 p. ; 20 cmContiene, in trad. italiana: Human rights and democracy, di D. Beetham; Principles of cosmopolitan democracy, di D. Archibugi. - Trad. della prima opera di Paola Ferretti. - Precede: La Dichiarazione universale dei diritti umani cinquant'anni dopo, degli stessi AA.001SUN00052722001 Elementi Feltrinelli. Società210 MilanoFeltrinelli.DemocraziaFISUNC001539Diritti dell'uomoFISUNC003313MilanoSUNL000284323Diritti civili e politici.21Archibugi, DanieleSUNV004824Beetham, DavidSUNV004825Koenig-Archibugi, MathiasSUNV004826FeltrinelliSUNV000132650ITSOL20181109RICASUN0005447UFFICIO DI BIBLIOTECA DEL DIPARTIMENTO DI GIURISPRUDENZA00 CONS VIII.Eh.127 00 14367 UFFICIO DI BIBLIOTECA DEL DIPARTIMENTO DI GIURISPRUDENZA14367CONS VIII.Eh.127paDiritti umani e democrazia cosmopolitica1438941UNICAMPANIA05459nam 2200673Ia 450 991083016190332120230617035347.01-280-51948-797866105194843-527-60375-13-527-60384-0(CKB)1000000000376379(EBL)481511(OCoLC)69243366(SSID)ssj0000211433(PQKBManifestationID)11201930(PQKBTitleCode)TC0000211433(PQKBWorkID)10293010(PQKB)11149194(MiAaPQ)EBC481511(EXLCZ)99100000000037637920040716d2005 uy 0engur|n|---|||||txtccrNitric oxide donors[electronic resource] for pharmaceutical and biological applications /edited by Peng George Wang, Tingwei Bill Cai, Naoyuki TaniguchiWeinheim ;[Great Britain] Wiley-VCHc20051 online resource (414 p.)Description based upon print version of record.3-527-31015-0 Includes bibliographical references and index.Nitric Oxide Donors; Contents; Preface; List of Contributors; Part 1 Chemistry of NO Donors; 1 NO and NO Donors; 1.1 Introduction to NO Biosynthesis and NO donors; 1.1.1 Nitric Oxide Synthases; 1.1.2 Chemistry of Reactive Nitrogen Species; 1.2 Classification of NO Donors; 1.3 New Classes of NO Donors under Development; 1.3.1 Nitroarene; 1.3.2 Hydroxamic Acids; 1.4 Development of NO-Drug Hybrid Molecules; 1.4.1 Nitrate Hybrid Molecules; 1.4.2 Furoxan Hybrid Molecules; 1.5 New Therapeutic Applications of NO Donors; 1.5.1 NO Donors against Cancer1.5.1.1 Diazeniumdiolates (NONOates) as Promising Anticancer Drugs1.5.1.2 The Synergistic Effect of NO and Anticancer Drugs; 1.5.1.3 NO-NSAIDs as a New Generation of Anti-tumoral Agents; 1.5.1.4 Other NO Donors with Anticancer Activity; 1.5.2 NO against Virus; 1.5.2.1 HIV-1 Induces NO Production; 1.5.2.2 Antiviral and Proviral Activity of NO; 1.5.3 Inhibition of Bone Resorption; 1.5.4 Treatment of Diabetes; 1.5.5 Thromboresistant Polymeric Films; 1.5.6 Inhibition of Cysteine Proteases; 1.6 Conclusion; References; 2 Organic Nitrates and Nitrites; 2.1 Organic Nitrates2.1.1 Direct Chemical Reaction between Organic Nitrates and Thiols2.1.2 Glutathione-S-transferase; 2.1.3 Cytochrome P-450-dependent Systems; 2.1.4 Membrane-bound Enzyme of Vascular Smooth Muscle Cells; 2.1.5 Xanthine Oxidoreductase; 2.1.6 Mitochondrial Aldehyde Dehydrogenase; 2.1.7 Tolerance; 2.2 Organic Nitrites; 2.3 Conclusions; References; 3 N-Nitroso Compounds; 3.1 Introduction; 3.2 N-Nitrosamines; 3.2.1 Synthesis of Nitrosamines; 3.2.2 Physical Properties and Reactions of N-Nitrosamines; 3.2.3 Structure-Activity Relationship of N-Nitrosamines; 3.2.4 Application of N-Nitrosamines3.3 N-Hydroxy-N-nitrosoamines3.3.1 Biologically Active N-Hydroxy-N-nitrosamine Compounds; 3.3.2 Synthesis of N-Hydroxy-N-nitrosamines; 3.3.3 Properties of N-Hydroxy-N-nitrosamines; 3.3.4 Reactivity of N-Hydroxo-N-nitrosamines; 3.4 N-Nitrosimines; 3.4.1 Mechanism of Thermal Reaction of N-Nitrosoimine; 3.4.2 Properties of N-Nitrosoimines; 3.4.3 Synthesis of N-Nitrosoimines; 3.5 N-Diazeniumdiolates; 3.5.1 Mechanism of NO Release; 3.5.2 Synthesis of N-Diazeniumdiolates; 3.5.2.1 Ionic Diazeniumdiolates; 3.5.2.2 O-derivatized Diazeniumdiolates; 3.5.3 Reactions of N-Diazeniumdiolates3.5.4 Clinical Applications3.5.4.1 Reversal of Cerebral Vasospasm; 3.5.4.2 Treatment of Impotency; 3.5.4.3 Nonthrombogenic Blood-contact Surfaces; 3.5.5 Future Directions; References; 4 The Role of S-Nitrosothiols in the Biological Milieu; 4.1 Structure and Cellular Reactivity of RSNOs; 4.1.1 RSNO Structure; 4.1.1.1 Enzymatic Consumption of RSNOs; 4.1.2 Formation of RSNOs in the Biological Milieu; 4.1.2.1 Nitrite Mediated; 4.1.2.2 NO Mediated; 4.1.2.3 NO Oxidation Products Mediated; 4.1.2.4 Metalloprotein Mediated; 4.1.2.5 Transnitrosation; 4.2 Postulated Physiological roles of RSNOs4.2.1 Regulation of Blood Flow by HbSNONitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes.In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.Nitric oxideNitric oxidePhysiological effectDrugsDesignPharmaceutical chemistryNitric oxide.Nitric oxidePhysiological effect.DrugsDesign.Pharmaceutical chemistry.572.54Wang Peng George738023Cai Tingwai Bill1611266Taniguchi Naoyuki1942-1611267MiAaPQMiAaPQMiAaPQBOOK9910830161903321Nitric oxide donors3939433UNINA