La crisi del contrattualismo / Guido Gonella

• Record Nr.: UNISALENTO991002449079707536
• Autore: Gonella, Guido
• Pubbl/distr/stampa: Milano : Giuffrè, 1959
• Edizione: [Nuova ed. del vol. pubbl. nel 1938]
• Descrizione fisica: 194 p. ; 25 cm.
• Collana: Pubblicazioni dell'Istituto di filosofia del diritto dell'Università di Roma ; 7
• Disciplina: 320.1
• Soggetti: Contrattualismo
• Lingua di pubblicazione: Italiano
• Formato: Materiale a stampa
• Livello bibliografico: Monografia

Circadian clocks / / Achim Kramer, Martha Merrow, editors

• Record Nr.: UNINA9910437852903321
• Pubbl/distr/stampa: Hoboken, N.J., : Springer, 2013
• ISBN: 9783642259500; 3642259502
• Edizione: [1st ed. 2013.]
• Descrizione fisica: 1 online resource (417 p.)
• Collana: Handbook of Experimental Pharmacology, , 0171-2004 ; ; 217
• Altri autori (Persone): KrämerAchim <1939->; MerrowMartha
• Disciplina: 571.77
• Soggetti: Circadian rhythms; Chronobiology
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes biliographical references and index.
• Nota di contenuto: Part I. Molecular and cellular basis of circadian clocks. Molecular ; components of the mammalian circadian clock. The epigenetic language of circadian clocks. Peripheral circadian oscillators in mammals. Cellular mechanisms of circadian pacemaking: beyond transcriptional loops. The clock in the brain: Neurons, glia and networks in daily rhythms -- Part II. Circadian control of physiology and behavior. Circadian clocks and metabolism. The circadian control of sleep. Daily regulation of hormone profiles. Circadian clocks and mood-related behaviors. Part III. Chronopharmacology and chronotherapy. Molecular Clocks in Pharmacology. Cancer chronotherapeutics: Experimental, theoretical and clinical aspects. Pharmacological modulators of the circadian clock as potential therapeutic drugs: Focus on genotoxic/anticancer therapy. Light and the human circadian clock -- Part IV. Systems biology of circadian clocks. Mathematical modeling in chronobiology. Mammalian circadian clock: the roles of transcriptional repression and delay. Genome-wide analyses of circadian systems. Proteomic approaches in circadian biology.
• Sommario/riassunto: This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.