Aluminum in biology and medicine

• Record Nr.: UNINA9911019621103321
• Pubbl/distr/stampa: Chichester [England] ; ; New York, : Wiley, 1992
• ISBN: 9786612347801; 9781282347809; 1282347802; 9780470514306; 0470514302; 9780470514313; 0470514310
• Edizione: [1st ed.]
• Descrizione fisica: 1 online resource (336 p.)
• Collana: Ciba Foundation symposium ; ; 169
• Altri autori (Persone): ChadwickDerek; WhelanJulie
• Disciplina: 612/.01524
• Soggetti: Aluminum - Physiological effect; Aluminum - Pathophysiology; Alzheimer's disease - Pathophysiology
• Lingua di pubblicazione: Inglese
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Note generali: Editors, Derek J. Chadwick (organizer) and Julie Whelan.; "A Wiley-Interscience publication."
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: ALUMINIUM IN BIOLOGY AND MEDICINE; Contents; Aluminium in biology: an introduction; Aluminium speciation in biology; Dietary and other sources of aluminium intake; The interrelationship between silicon and aluminium in the biological effects of aluminium; The epidemiology of Alzheimer's disease in relation to aluminium; Aluminium and the pathogenesis of Alzheimer's disease: a summary of evidence; Intestinal absorption of aluminium; Aluminium intoxication in renal disease; Aluminium and Alzheimer's disease; Aluminium accumulation, B-amyloid deposition and neurofibrillary changes in the central nervous systemAluminium(III) in experimental cell pathology; Elemental analysis of neurofibrillary tangles in Alzheimer's disease using proton-induced X-ray analysis; Aluminium and the neurofibrillary tangle: results of tissue microprobe studies; Intracellular effects of aluminium on receptor-activated cytoplasmic Ca2+ signals in pancreatic acinar cells; Neurotoxic effects of dietary aluminium; Molecular characterization and measurement of Alzheimer's disease pathology: implications for genetic and environmental aetiologySumming-up; Index of contributors; Subject index
• Sommario/riassunto: Prominent contributors address issues regarding the toxicity of aluminum which causes an encephalopathy in renal dialysis patients and is also known to damage animals and plants via acid rain. Examines the chemistry and biology of aluminum compounds focusing on the evidence for and against aluminum's role in Alzheimer's disease.