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1. |
Record Nr. |
UNICASUBO1786705 |
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Titolo |
Guide to European valves for control, isolation and safety : The practical reference book covering valves, their design, selection, applications, and uses. Including a comprehensive buyers guide to European manufacturers and suppliers / edited by Brian Nesbitt |
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Pubbl/distr/stampa |
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Bury St Edmunds and London, : Professional Engineering Publishing, 2001 |
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ISBN |
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Edizione |
[2. ed] |
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Descrizione fisica |
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[XVI], 440 p. : ill. ; 30 cm. |
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Disciplina |
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Soggetti |
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Automazione a fluido |
Valvole |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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2. |
Record Nr. |
UNISA996582066503316 |
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Autore |
Schenker Ina |
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Titolo |
Auditives Erzählen : Dem Leben lauschen: Hörspielserien aus transnationaler und transmedialer Perspektive |
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Pubbl/distr/stampa |
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Bielefeld : , : transcript, , 2022 |
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©2022 |
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ISBN |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (255 pages) |
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Collana |
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Soggetti |
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LITERARY CRITICISM / General |
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Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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Frontmatter -- Inhalt -- Danksagung -- Dem Leben lauschen: Einleitung -- 1 Denk- und Vorgehensweisen einer transnationalen und transmedialen Literaturwissenschaft -- 1.1 Globalisierung und Postkolonialismus -- 1.2 Modi des Auditiven -- 1.3 Serielles Erzählen -- 1.4 Medientexte und Wissen -- 2 Auditive Medienkulturen und -texte: Ansätze eines Hörspielmappings -- 2.1 Der deutschsprachige Raum: »ein spezial gelagerter Sonderfall« -- 2.2 Hörspiel, Radio Drama, pièce radiophonique, radioteatro … -- 3 Hörspielserien in postkolonialen Kontexten -- 3.1 Kultur- und mediengeschichtliche Bewegungen -- 3.2 Wanderungen eines Genres: Radio Soap Operas -- 3.3 Powerful stories, powerful media experiences, powerful roles: Edutainment -- 3.4 Dem Leben lauschen: Vivra Verra und Echoes of Change -- 3.5 Weltbilder modellieren: Lernprozesse und Reflexionspotenziale -- 4 Hörspielserien transmedial: zum Refashioning von Erzählverfahren -- 4.1 Erzählen im neuen Gewand: Shuga und You Me… Now! -- 4.2 Dem Leben lauschen: Shuga und You Me… Now! -- Dem Leben lauschen: Schlussbemerkungen -- Literaturverzeichnis -- Abbildungsverzeichnis |
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Sommario/riassunto |
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Hörspielserien erzählen Geschichten und zugleich von ihren Produktions- und Rezeptionskontexten. Ina Schenker setzt mit einer transnationalen und transmedialen Perspektive exemplarische radio dramas aus Ozeanien und Subsahara-Afrika in Bezug zur deutschsprachigen auditiven Medienkultur. Philologische Rahmungen |
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werden agil, was nicht nur dem inhaltlichen Bezug zu Diskursen rund um Leben und Wissen geschuldet ist, sondern auch den Ausdrucksformen der Hörspielserien selbst. Auditives Erzählen ist vielschichtig: es regt an und auf, gibt Motivation und unterhält, weckt Emotionen und Geschichten - ist politisch und partizipativ. |
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3. |
Record Nr. |
UNINA9910345960703321 |
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Autore |
Timothy D. Hewitson |
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Titolo |
Novel Therapeutic Targets and Emerging Treatments for Fibrosis |
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Pubbl/distr/stampa |
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Descrizione fisica |
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1 online resource (162 p.) |
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Collana |
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Frontiers Research Topics |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs.Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder.This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis |
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including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facilitating tissue repair. Finally, this Research Topic concludes with a clinical perspective of various anti-fibrotic therapies for cardiovascular disease (CVD), outlining limitations of currently used therapies, the pipeline of anti-fibrotics for CVD and why so many anti-fibrotic drugs have failed at the clinical level. |
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