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Record Nr. |
UNISA996465443403316 |
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Autore |
LuÌ Jinhu |
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Titolo |
Modeling and analysis of bio-molecular networks / / Jinhu LuÌ, Pei Wang |
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Pubbl/distr/stampa |
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Singapore : , : Springer, , [2020] |
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©2020 |
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ISBN |
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Edizione |
[1st ed. 2020.] |
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Descrizione fisica |
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1 online resource (XXI, 464 p. 144 illus., 123 illus. in color.) |
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Disciplina |
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Soggetti |
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Molecular biology - Data processing |
Computational biology |
Bioinformatics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Nota di contenuto |
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1 Introduction and Preliminaries -- 2 Reconstruction of Bio-molecular Networks -- 3 Modeling and Analysis of Simple Genetic Circuits -- 4 Modeling and Analysis of Coupled Bio-molecular Circuits -- 5 Modeling and Analysis of Large-scale Networks -- 6 Evolutionary Mechanisms of Network Motifs in PPI Networks -- 7 Identifying Important Nodes in Bio-molecular Networks -- 8 Statistical Analysis of Functional Genes in Human PPI Networks -- 9 Data-driven Statistical Approaches for Omics Data Analysis. |
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Sommario/riassunto |
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This book addresses a number of questions from the perspective of complex systems: How can we quantitatively understand the life phenomena? How can we model life systems as complex bio-molecular networks? Are there any methods to clarify the relationships among the structures, dynamics and functions of bio-molecular networks? How can we statistically analyse large-scale bio-molecular networks? Focusing on the modeling and analysis of bio-molecular networks, the book presents various sophisticated mathematical and statistical approaches. The life system can be described using various levels of bio-molecular networks, including gene regulatory networks, and protein-protein interaction networks. It first provides an overview of approaches to reconstruct various bio-molecular networks, and then |
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discusses the modeling and dynamical analysis of simple genetic circuits, coupled genetic circuits, middle-sized and large-scale biological networks, clarifying the relationships between the structures, dynamics and functions of the networks covered. In the context of large-scale bio-molecular networks, it introduces a number of statistical methods for exploring important bioinformatics applications, including the identification of significant bio-molecules for network medicine and genetic engineering. Lastly, the book describes various state-of-art statistical methods for analysing omics data generated by high-throughput sequencing. This book is a valuable resource for readers interested in applying systems biology, dynamical systems or complex networks to explore the truth of nature. |
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