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1. |
Record Nr. |
UNISA996418278303316 |
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Autore |
Held Leonhard |
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Titolo |
Likelihood and Bayesian Inference [[electronic resource] ] : With Applications in Biology and Medicine / / by Leonhard Held, Daniel Sabanés Bové |
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Pubbl/distr/stampa |
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Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2020 |
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ISBN |
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Edizione |
[2nd ed. 2020.] |
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Descrizione fisica |
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1 online resource (XIII, 402 p. 84 illus.) |
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Collana |
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Statistics for Biology and Health, , 1431-8776 |
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Disciplina |
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Soggetti |
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Statistics |
Biostatistics |
Ecology |
Biomathematics |
Statistics for Life Sciences, Medicine, Health Sciences |
Statistical Theory and Methods |
Bayesian Inference |
Theoretical Ecology/Statistics |
Genetics and Population Dynamics |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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This richly illustrated textbook covers modern statistical methods with applications in medicine, epidemiology and biology. Firstly, it discusses the importance of statistical models in applied quantitative research and the central role of the likelihood function, describing likelihood-based inference from a frequentist viewpoint, and exploring the properties of the maximum likelihood estimate, the score function, the likelihood ratio and the Wald statistic. In the second part of the book, likelihood is combined with prior information to perform Bayesian inference. Topics include Bayesian updating, conjugate and reference priors, Bayesian point and interval estimates, Bayesian asymptotics and empirical Bayes methods. It includes a separate chapter on modern |
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numerical techniques for Bayesian inference, and also addresses advanced topics, such as model choice and prediction from frequentist and Bayesian perspectives. This revised edition of the book “Applied Statistical Inference” has been expanded to include new material on Markov models for time series analysis. It also features a comprehensive appendix covering the prerequisites in probability theory, matrix algebra, mathematical calculus, and numerical analysis, and each chapter is complemented by exercises. The text is primarily intended for graduate statistics and biostatistics students with an interest in applications. |
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2. |
Record Nr. |
UNICASTO00803676 |
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Titolo |
4: Antologia |
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Pubbl/distr/stampa |
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ISBN |
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Descrizione fisica |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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3. |
Record Nr. |
UNINA9910963123103321 |
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Autore |
Holmes Frederic Lawrence |
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Titolo |
Meselson, Stahl, and the replication of DNA : a history of "the most beautiful experiment in biology" / / Frederic Lawrence Holmes |
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Pubbl/distr/stampa |
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New Haven, CT, : Yale University Press, 2001 |
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ISBN |
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9786611730451 |
9781281730459 |
1281730459 |
9780300129663 |
0300129661 |
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Edizione |
[1st ed.] |
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Descrizione fisica |
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1 online resource (1 online resource (xii, 503 p.) ) : ill |
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Disciplina |
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Soggetti |
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DNA replication - Experiments - History |
Molecular biology - Experiments - History |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Bibliographic Level Mode of Issuance: Monograph |
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Nota di bibliografia |
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Includes bibliographical references (p. [449]-496) and index. |
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Nota di contenuto |
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Machine generated contents note: Chapter One The Replication Problem 11 -- Chapter Two Meselson and Stahl 49 -- Chapter Three Twists and Turs 75 -- Chapter Four Crossing Fields: Chemical Bonds to Biological Mutants 116 -- Chapter Five Dense Solutions 157 -- Chapter Six The Big Machine 183 -- Chapter Seven Working at High Speed 215 -- Chapter Eight The Unseen Band 272 -- Chapter Nine One Discovery, Three Stories 303 -- Chapter Ten An Extremely Beautiful Experiment 319 -- Chapter Eleven Centrifugal Forces 352 -- Chapter Twelve The Subunits of Semiconservative Replication 388 -- Chapter Thirteen Images of an Experiment 412 -- Chapter Fourteen Afterword 435. |
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Sommario/riassunto |
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In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest.This book vividly reconstructs the complex route that led |
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to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment. |
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