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1. |
Record Nr. |
UNISA996396645103316 |
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Autore |
Hawkins John <17th cent.> |
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Titolo |
The clerk's tutor for writing [[electronic resource] /] / Written and engraved by Edw. Cocker |
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Pubbl/distr/stampa |
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London, : Printed for Jo. Streater, Ja. Flesher, and Hen. Twyford. Sold in Vine Court Middle Temple, 1667 |
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Descrizione fisica |
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[12], 360 p., [6] leaves of plates |
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Altri autori (Persone) |
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CockerEdward <1631-1675.> |
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Soggetti |
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Copybooks - England |
Forms (Law) - England |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Note generali |
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Engraved t.p. containing a perpetual almanac; six leaves of writing specimens. |
"This book is by Hawkins ... and the t.p. only claims the plates, not the letterpress for Cocker"--DNB (concerning The young clerk's tutor for writing, 1st ed., 1660?). |
Reproduction of original in Newberry Library. |
Imperfect: lacks p. 185-208. |
This item is identified at reel 22:9 as Wing C4832A (number cancelled in Wing CD-ROM, 1996), and at reel 2265:8 as Wing (CD-ROM, 1996) H1174A. |
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Sommario/riassunto |
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2. |
Record Nr. |
UNINA9910585941103321 |
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Autore |
Levtchenko Elena N |
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Titolo |
Cellular and Molecular Mechanisms of Nephropathic Cystinosis |
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Pubbl/distr/stampa |
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Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
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Descrizione fisica |
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1 online resource (230 p.) |
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Soggetti |
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Medicine and Nursing |
Pharmacology |
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Lingua di pubblicazione |
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Formato |
Materiale a stampa |
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Livello bibliografico |
Monografia |
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Sommario/riassunto |
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Nephropathic cystinosis (MIM # 219800) is a rare autosomal recessive disorder caused by mutations in the lysosomal cystine transporter cystinosin, encoded by the CTNS gene (17p13.2). This devastating condition initially affects kidneys and subsequently many other organs including eyes, thyroid, pancreas, muscles, and brain. While lysosomal cystine storage is a key feature of the disease and the main target of current therapy, recent groundbreaking research has revealed that cystinosin has diverse functions in cells, being involved in vesicle trafficking, energy homeostasis, and cell death mechanisms. These discoveries deepen our insights into the mechanisms of cystinosis and of lysosomal biology in general. In this Special Issue dedicated to the pioneer of cystinosis research Dr. Jerry Schneider, we highlight the state-of-the-art understanding of cellular and molecular mechanisms of various disease features, opening new horizons for innovative treatment strategies for cystinosis and potentially other lysosomal storage diseases. |
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